Anti Neurocan Peptides - Cosmo Bio Co.,Ltd.

Antibodies

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Anti Neurocan Peptides Antibody

Catalog No.: CAC-NU-07-005
Size: 200UL
Price: ¥50000
$667
antigen/source: Neurocan Peptides
host: Rabbit
Description: Synthetic peptide, [epitope]a.a. 483-498
Label: Unlabeled
Purity: Serum
Application: Western Blot
IHC paraffin embedding section
Storage: -20C
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Immunogen: Rat
Reacts with: Mouse
Rat
Shape: Liquid
component: [Application]
Western blotting: 1/200
Immunohistochemistry (Paraffin): 1/200
Other applications have not been tested.
Optimal dilutions/concentrations should be determined by the end user.
Cross reactivity: Rat, Mouse

Other:

 Background 
Neurocan is a nervous tissue-unique, secretory proteoglycan that carries predominantly chondroitin sulfate side chains. Its expression gradually decreases with the nervous tissue development. In the immature brain, neurocan exists inafull-length form with a 240 kDa-core glycoprotein, whereas it exists totally in proteolytic fragments of the NH2-terminal half (neurocan-N) with a 130 kDa-core glycopeptide and the COOH-terminal half (neurocan-C) with a 150 kDa-core glycopeptide. Neurocan is implicated in the neural network formation, and is a susceptibility factor for bipolar disorder. This proteoglycan is upregulated in the lesion site of the central nervous system, and is a major component of the glial scar. In addition, neurocan-N, not neurocan-C, is detectable in the perineuronal nets of some neurons. This antibody recognizes effectively neurocan-N as well as the full-length neurocan.



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Reference:

•  Matsui, F., Watanabe, E., & Oohira, A., (1994) Neurochem. Int., 25, 425-431.
•  Oohira, A., Matsui, F., Tokita,Y., Yamauchi, S., & Aono, S., (2000) Arch. Biochem. Biophys., 374, 24-34.
•  Fumiko Matsui, Masako Nishizuka, Yoko Yasuda, Sachiko Aono, Eiji Watanabe, Atsuhiko Oohira .,(1998) Brain Res., 790, 45-51
 
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