SAFETRANS (Lac- α -CDE) - Cosmo Bio Co.,Ltd.




Catalog No.: CSR-KMU-T03
Size: 2MG
Price: [DISCONTINUED] Sorry!! This product is not available anymore.
Storage: -20C
Purpose: pDNA and siRNA transfection


It is well-known that asialoglycoprotein receptor (ASGPR) highly expresses on hepatocyte cell surface. Recently, lactosylated polyamidoamine (PAMAM) dendrimer (generation (G) 2) conjugate with a-cyclodextrin (Lac- α -CDE) has been known as hepatocyte-selective DNA and siRNA carriers through ASGPR-mediated endocytosis with negligible cytotoxicity in vitro and in vivo.
[pDNA Transfection]
In the case of charge ratio 100 (carrier/pDNA)
[siRNA Transfection]
In the case of a charge ratio of 50 (carrier/siRNA)


•  Kihara F. et al., Bioconjug. Chem., 14 342-350 (2003)
•  Kihara F. et al., Bioconjug. Chem., 13 211-1219 (2002)
•  Arima H. et al., Bioconjug. Chem., 12 476-484 (2001)
•  Tsutsumi T. et al., J. Pharm. Sci., 97