Anti SIRP β - Cosmo Bio Co.,Ltd.

Antibodies

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Anti SIRP β Antibody

Catalog No.: CAC-GU02-P01AF-A
Size: 50UL
Price: [DISCONTINUED] Sorry!! This product is not available anymore.
antigen/source: SIRP beta
host: Rabbit
Label: Unlabeled
Purity: Affinity Purified
Application: Western Blot
catalog info: Catalog 2012-p89
Storage: -20C
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Immunogen: Mouse
Reacts with: Mouse

Other:

 Background 
SIRP (signal-regulatory protein ) is a transmembrane protein that is expressed in hematopoietic cells. It has been suggested that SIRP promotes phagocytosis in macrophages by inducing the tyrosine phosphorylation of DAP12, Syk,and SLP-76 and the subsequent activation of a MEK-MAPK-myosin light chain kinase cascade (ref. 1).
 Application 
Western Blot: 1/100-1/200.
(Predicted molecular weight: 50-70 kDa)
Optimal dilutions/concentrations should be determined by the end user.


Reference:

•  Hiroshi Ikeda, Sei-ichiro Motegi, Naoko Aoki, Shoji Kimura, Masahiko Mizuki and Takashi Matozaki Positive Regulation of Phagocytosis by SIRP and Its Signaling Mechanism in Macrophage The Journal of Biological Chemistry Vol.279 No.28, pp29450-29460
 
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