Anti Neuroglycan C - Cosmo Bio Co.,Ltd.

Antibodies

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Anti Neuroglycan C Antibody

Catalog No.: CAC-NU-07-003
Size: 200UL
[1 mg / mL]
Price: ¥50000
$667
antigen/source: Neuroglycan C
host: Mouse
Description: Membrane-bound chondroitin sulfate proteoglycans purified from 10-day-old rat brains
Purity: Ig fraction - Protein G
Application: Western Blot
Immunoprecipitation
IHC frozen section
IHC paraffin embedding section
Storage: -20C
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Immunogen: Rat
Isotype: IgG1
Clone: C1
Reacts with: Rat
Purpose: Western blotting: 1/10,000
- Immunohistochemistry: 1/200 (Paraffin section), 1/500 - 1/1000 (Frozen section)
- Immunoprecipitaion: 1/500
Other applications have not been tested.
Optimal dilutions/concentrations should be determined by the end user.

Other:

[BACKGROUND]
Neuroglycan C (NGC/CALEB) is a transmembrane-type of chondroitin sulfate proteoglycan with a core glycoprotein of
120 kDa, and is exclusively expressed in the central nervous system. NGC expression is developmentally regulated, andis altered by addiction to psychostimulants as well as by nerve lesions. NGC is a novel part-time proteoglycan that changes its structure from a proteoglycan form to a non-proteoglycan form without chondroitin sulfate side chains during the development of the cerebellum and retina. NGC gene is a potential susceptibility gene for schizophrenia.
This antibody recognizes effectively the core glycoprotein of NGC.



 IMAGE1



Characterization of the monoclonal anti-neuroglycan C antibody (clone C1) Immunoblotting using the anti-neuroglycan C antibody of a partially purified preparation of membrane-bound proteoglycans from brains of 10-day-old rats (lane 1), and that digested with chondroitinase ABC (CHase ABC; lane 2). Reference: J. Biol. Chem., 270 (1995) 26876-26882

Reference:

•  Watanabe, E., et al., J. Biol. Chem, 270, 26876-26882 (1995)
•  Shuo, T., et al., Glycoconj. J., 20, 257-278 (2004)
•  Oohira, A., et al., Glycoconj. J., 21, 53-57 (2004)
•  Ichihara-Tanaka, K., et al., J. Biol. Chem., 281, 30857-30864 (2006)
 
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