Anti α Synuclein (9 antibodies set) - Cosmo Bio Co.,Ltd.

Antibodies

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Anti α Synuclein (9 antibodies set) Antibody

Catalog No.: CAC-TIP-SN-SET
Size: 9*10UL
Price: ¥90000
$1200
antigen/source: alpha Synuclein (9 antibodies set)
host: Rabbit
Purity: Serum
Application: Immunohistochemistry
Western Blot
Storage: -20C
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Isotype: IgG
Reacts with: Human

Other:

 Background 
Alpha-Synuclein, a 140-amino acid protein abundantly expressed in presynaptic terminals, is known as a component of
intraneuronal or glial inclusions observed in cases of Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and
Multiple system atrophy (MSA). Alpha-Synuclein is a natively unfolded protein, however, fibrillization or conformational
change of Alpha-synuclein is central in the pathogenesis of Alpha-synucleinopathies. The amino-terminal region of
Alpha-synuclein consists of seven imperfect repeats, each 11 amino acids in length, with the consensus sequence
KTKEGV. The repeats partially overlap with a hydrophobic region (amino acids 61-95). The carboxy-terminal region
(amino acids 96-140) is negatively charged. These antibodies are powerful tools for biochemical and IHC analyses of
neurodegenerative diseases and for evaluation of conformational changes of Alpha-synuclein.


Reference:

•  Masami Masudaet al.,FEBS Letters 583, 787-791(2009). PMID 19183551
•  Motokuni Yonetaniet al.,Journal of Biological Chemistry 284, 7940-7950(2009). PMID 19164293
 
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