Anti APP - Cosmo Bio Co.,Ltd.

Antibodies

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Anti APP Antibody

Alzheimer amyloid precursor protein

Catalog No.: BAM-74-104-EX
Size: 100UL
Price: ¥34500
$460
antigen/source: APP
host: Rabbit
Description: [Immunogen]C-terminal, a.a. 671-695
Purity: Serum
Application: Western Blot
Enzyme Linked Immunosorbent Assay
catalog info: Catalog 2012-p8
Storage: -20C
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Immunogen: Human
Clone: AC1
Reacts with: Human
Mouse
Rat



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Fig.1 Endogenous expression of APP in mouse P19 cells during neural differentiation was analysed by Western blotting using this antibody (ref.2). lane1, undifferentiated P19 cells (U); lane2, day 3; lane3, day4; lane4, day7; lane5, day12; lane6, day15; lane7, day17. APP species with 105-120K markedly increased during days 3-12, but declined thereafter. On the other hand, APP species with 115-130K were detected on day 15 and 17.

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Fig.2 Immunocytochemistry for APP (ref 4). Mouse dorsal root ganglion neurons were cultured in the presence of nerve growth factor (NGF), fixed at indicated time points, and immunostained for the C-terminus of APP with this antibody. Left panels are differential interference contrast images of the same fields. APP immunoreactivity was very low at 0 h but increased in neuronal somata (arrows), neurites (arrowheads) 3-12 h after NGF treatment, a period when neurites showed a marked outgrowth. APP immunoreactivity decreased at 36 h.
 
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