Anti Klotho - Cosmo Bio Co.,Ltd.

Antibodies

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Anti Klotho Antibody

Catalog No.: KAL-KO604
Size: 50UG
Price: ¥55000
$734
antigen/source: Klotho
host: Rat Mono
Description: [Epitope] 801-954a.a.
Label: Unlabeled
Purity: Ig fraction - Protein G
Application: Western Blot
Immunohistochemistry
Storage: -20C
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Immunogen: Human
Isotype: IgG2b
Clone: KM2119
Reacts with: Human
Mouse

Other:

[Gene Symbol] KL
[Gene ID] 9365
[Concentration] 0.25mg/mL
[Function]
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may beinactive as aglycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.



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Reference:

•  Kato Y. et al., Biochem Biophys Res Commun. 19:267 597-602 (2000)
•  Tohyama O. et al., J Biol Chem. 12:279 9777-9784 (2004)
•  Imura A. et al., FEBS Left. 7:565 143-147 (2004)
•  Imura A. et al., Science. 15:316 1615-1618 (2007)
•  Brownstein CA. et al., Proc Natl Acad Sci. 4:105 3455-3460 (2008)
 
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