SAFETRANS ( α -CDE) - Cosmo Bio Co.,Ltd.

Antibodies

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SAFETRANS ( α -CDE)

Catalog No.: CSR-KMU-T01
Size: 2MG
[2 mg]
Price: [DISCONTINUED] Sorry!! This product is not available anymore.
catalog info: 2011 Japanes Assay kit Catalog-p950
Storage: -20C
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Purpose: Superior nucleic acids carrier without severe cytotoxicity in vitro and in vivo.

Other:

 Background 
Gene and oligonucleotide therapies are emerging as a potential strategy for the treatment of genetic diseases, cancers, cardiovascular diseases and infectious diseases. Recently, polyamidoamine (PAMAM) dendrimer (generation (G) 3) conjugate with (alpha)-cyclodextrin ((alpha)-CDE) has been known as novel DNA, shRNA and siRNA carriers. α -CDE works as a superior nucleic acids carrier without severe cytotoxicity in vitro and in vivo.
[Storage]
[pDNA Transfection]
In the case of charge ratio 100 (carrier/pDNA)
[siRNA Transfection]
In the case of a charge ratio of 50 (carrier/siRNA)
[Cells with compatibility]
A549
NIH3T3
Colon-26
HepG2
NR8383
RAW264.7
KB





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Reference:

•  Kihara F. et al., Bioconjug. Chem., 14 342-350 (2003)
•  Kihara F. et al., Bioconjug. Chem., 13 211-1219 (2002)
•  Arima H. et al., Bioconjug. Chem., 12 476-484 (2001)
•  Tsutsumi T. et al., J. Pharm. Sci., 97
 
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