SAFETRANS (GUG- β -CDE) - Cosmo Bio Co.,Ltd.

Antibodies

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SAFETRANS (GUG- β -CDE)

Catalog No.: CSR-KMU-T02
Size: 2MG
[2 mg]
Price: [DISCONTINUED] Sorry!! This product is not available anymore.
catalog info: 2011 Japanes Assay kit Catalog-p950
Storage: -20C
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Purpose: Superior nucleic acids carrier without severe cytotoxicity in vitro and in vivo.

Other:

 Background 
The polyamidoamine (PAMAM) starburst dendrimer (generation 2, G2) conjugates with 6-O- α -(4-O- α -D-glucuronyl)-D-glucosyl- β -cyclodextrin?(GUG- β -CDE (G2)) having glucose as a spacer between dendrimer and cyclodextrin(CyD) was newly prepared as a novel gene transfer carrier. GUG- β -CDE (G2) was found to have lower hemolytic activity than dendrimer (G2), suggesting that GUG- β -CDE (G2) had lower local irritation than dendrimer (G2). In sharp contrast to linear polyethyleneimine (10 kDa, PEI), GUG- β -CDE (G2, DS 1.8) had negligible cytotoxicity. GUG- β -CDE works as a superior nucleic acids carrier without severe cytotoxicity in vitro and in vivo.
[pDNA Transfection]
In the case of charge ratio 100 (carrier/pDNA)


Reference:

•  Kihara F. et al., Bioconjug. Chem., 14 342-350 (2003)
•  Kihara F. et al., Bioconjug. Chem., 13 211-1219 (2002)
•  Arima H. et al., Bioconjug. Chem., 12 476-484 (2001)
•  Tsutsumi T. et al., J. Pharm. Sci., 97
 
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