Anti 4R-tau - Cosmo Bio Co.,Ltd.

Antibodies

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Anti 4R-tau Antibody

Catalog No.: CAC-TIP-4RT-P01
Size: 50UL
Price: ¥50000
$667
antigen/source: 4R-tau peptide
host: Rabbit
Description: Synthetic N279D 4R-tau peptide (VQIIDKKLDLSNVQSKC)
Label: Unlabeled
Purity: Serum
Application: Western Blot
Immunohistochemistry
Storage: -20C
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Immunogen: Human
Isotype: IgG
Reacts with: Human
Mouse
Rat

Other:

 Background 
Tau is a microtubule-associated protein. In adult human brain, 6 tau isoforms are expressed, which are divided into two
groups, 3-repeat (3R) and 4-repeat (4R) tau isoforms. Tau assembles into insoluble, filamentous, and
hyperphosphorylated inclusions in many neurodegenerative diseases, and different tau isoforms are accumulated in the
diseased brains, namely, 6 tau isoforms in AD, 3R tau isoforms in Pickfs disease, and 4R tau isoforms in PSP and CBD.
Therfore, isoform-specific tau antibodies are useful tools for immunohistochemical and biochemical studies of tau
species in diseased brains. Tau deposited in AD is extensively deamidated at N279. This anti-4R specifically recognizes
4R tau isoforms regardless of deamidation and strongly stained tau in AD brain.
[Immunogen]
synthetic N279D 4R-tau peptide (VQIIDKKLDLSNVQSKC)
 Cross reactivity 
Human, Mouse, Rat



 IMAGE1



Fig1: Immuno blot analysis for 6 kinds of tau isoforms (3-repeat and 4-repeat) with anti total tau (T46) and Anti 4R (TIP-4RT-P01).

 IMAGE2



Fig2: Immuno staining for paraffin embedded section of cerebral cortex prepared from AD brain (retrieved with proteinase K and formic acid)

Reference:

•  Hasegawa M.et al.,,Acta Neuropathol.Nov 9 (2013)
•  Dan A.et al., Acta Neuropathologica Communications,1:54 (2013)
 
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