Anti C9orf72 (Poly-GA) - Cosmo Bio Co.,Ltd.

Antibodies

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Anti C9orf72 (Poly-GA) Antibody

Catalog No.: CAC-TIP-C9-P01
Size: 50UL
Price: ¥40000
$534
antigen/source: C9orf72
host: Rabbit
Description: Poly-GA
Label: Unlabeled
Application: Enzyme Linked Immunosorbent Assay
Immunohistochemistry
Storage: -20C
@
Immunogen: Human
Isotype: IgG
Reacts with: Human

Other:

 Background 
Hexanucleotide expansions in C9orf72 gene was identified in patients with frontotemporal lobar degeneration (FTLD)
and Amyotrophic Lateral Sclerosis (ALS) in 2011. GGGGCC expansions are characterised pathologically by the
presenceof TDP-43 negative and p62 positive inclusions in granule cells of cerebellum and in cells of dentate gyrus and
CA4 area of the hippocampus. It was reported that these inclusions included dipeptide repeat proteins, poly-GA,
poly-GR and poly GP,arising from a putative non-ATG initiated sense translation of the GGGGCC expansion. These
antibodies are powerful tools for IHC analysis of neurodegenerative diseases.
 Cross reactivity 
Human
 Application 
EELISA
EImmunohistochemistry: 1/500-1/2000 (Ref.1)
Other applications have not been tested. Optimal dilutions/ concentrations
should be determined by the end user.



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Reference:

•  David MA Mann et al., Acta Neuropathologica Communications 1:68. PMID 24252525 (2013)
 
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