Anti C9orf72 (Poly-GR) - Cosmo Bio Co.,Ltd.

Antibodies

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Anti C9orf72 (Poly-GR) Antibody

Catalog No.: CAC-TIP-C9-P02
Size: 50UL
Price: ¥40000
$534
antigen/source: C9orf72
host: Rabbit
Description: Poly-GR
Label: Unlabeled
Purity: Serum
Application: Enzyme Linked Immunosorbent Assay
Immunohistochemistry
Storage: -20C
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Immunogen: Human
Isotype: IgG
Reacts with: Human

Other:

 Background 
Hexanucleotide expansions in C9orf72 gene was identified in patients with Frontotemporal Lober Degeratation (FTLD)
and Amyotrophic Lateral Sclerosis (ALS) in 2011. GGGGCC expansions are characterised pathologically by the
presence of TDP-43 negative and p62 positive
inclusions in granule cells of cerebellum and in cells of dentate gyrus and
CA4 area of the hippocampus. It was reported that these inclusions included dipeptide repeat proteins, poly-GA,
poly-GR and poly GP,arising from a putative non-ATG initiatedsense translation of the GGGGCC expansion. These
antibodies are powerful tools for IHC analysis of neurodegenerative diseases.
 Cross reactivity 
Human
 Application 
EELISA: 1/1000-1/2000
EImmunohistochemistry: 1/500-1/2000 (Ref.1)
Other applications have not been tested. Optimal dilutions/ concentrations
should be determined by the end user.


Reference:

•  David MA Mannet al., Acta Neuropathologica Communications 1:68. PMID 24252525 (2013)
 
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