Anti COMP Fragment (2127F5) - Cosmo Bio Co.,Ltd.

Antibodies

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Anti COMP Fragment (2127F5) Antibody

Catalog No.: CAC-PRPG-CPF-M02
Size: 2ML
Price: ¥55000
$734
antigen/source: COMP Fragment (2127F5)
host: Mouse
Purity: Supernatant
Application: Western Blot
IHC paraffin embedding section
Enzyme Linked Immunosorbent Assay
Immunoprecipitation
Storage: -20C
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Immunogen: Human
Isotype: IgG1
Clone: 2127F5
Reacts with: Human

Other:

 Background 
COMP - Cartilage oligomeric matrix protein - belongs to the thrombospondin family of ECM components and is a prominent multidomain glycoprotein of cartilage, accounting for up to 1% of the wet weight of articular tissues and having anapproximate Mr of 97 kDa [1-4]. COMP may also be found in tendon, bone (i.e. osteoblasts), ligament, certain smooth muscles and synovium and more recently has been discovered to be a primary constituents of the dermal ECM [5]. In the ECM COMP is present in a pentameric, disulfide-bonded complex of an Mr of about 550 kDa, often seen associated with the chondrocyte cell surface [3, 5]..
[Immunogen]
Recombinant EGF domain of human COMP
 Specificity 
COMP (Cartilage Oligomeric Matrix Protein)



 IMAGE1



Left panel: Western blotting on recombinant COMP produced in HEK293 cells after SDS-PAGE under reducing conditions on 8% gels. Lanes 1 and 2 from left show secreted and cell-bound COMP, whereas the two adjacent lanes show the controls. Right panels: immunohistochemical stainings of human articular cartilage at lower (left) and higher magnification (right).

Reference:

•  Oldberg A, et all., J Biol Chem. 1992 Nov 5;267(31):22346-50. PMID: 1429587
•  Hedbom E, et all., J Biol Chem. 1992 Mar 25;267(9):6132-6.. PMID: 1556121
•  Morgelin M, et all., J Biol Chem. 1992 Mar 25;267(9):6137-41.PMID: 1556122
•  Cesare PE, et all., J Orthop Res. 1995 May;13(3):422-8.. PMID: 7602403
•  Agarwal P, et all., J Biol Chem. 2012 Jun 29;287(27):22549-59. PMID: 22573329
 
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