Anti Integrin α 6 (537D5) - Cosmo Bio Co.,Ltd.

Antibodies

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Anti Integrin α 6 (537D5) Antibody

Catalog No.: CAC-PRPG-ITG-M01
Size: 20UL
Price: ¥55000
$734
antigen/source: Integrin α 6 (537D5)
host: Mouse
Purity: Supernatant
Application: Western Blot
Immunocytochemistry (cell)
Storage: -20C
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Immunogen: Human
Isotype: IgG1
Clone: 537D5
Reacts with: Human

Other:

Integrins are conserved, cation-dependent transmembrane receptors essential for cell survival and growth, which are
composed of an and a subunit that are differentially involved in ligand binding and connection with the cytoskeleton.
They are specialized in linking cells to the extracellular matrix (ECM) and to cell surface-bound adhesion molecules,
such as to allow cells to properly organize within tissues in relation to the underlying and/or surrounding matrices. Thus,
in epithelia and vasculature integrins are central elements in the structuring the intricate junctional complexes with the
underlying basement membranes, whereas in connective tissues they allow the cells to form stable attachments (i.e.
focal adhesions) with their surrounding interstitial matrices and rapidly convert (bidirectionally) from stationary to motile
phenotypes. Integrins not engaged in ligand binding are generally dispersed on the surface of cells, but tend to form
microclusters. Upon ligand engagement they reorganize to form larger clusters that permit the stabilization of the
cell-ECM or cell-cell interactions.
Simultaneously, through phosphorylation of the cytoplasmic portion of the subunit, they associated with key
cytoskeletal adapter proteins, such as vinculin, talin, paxillin, tensin and FAK and activate complex signal transduction
pathways converging with those elicited by growth factor receptors and other receptors for soluble and
membrane-bound signal molecules. This results in the activation of the cell cycle, cell differentiation programs and/or the
acquisition of motile properties. Conversely, loss of integrin binding to the matrix causes a defined programmed cell
death known as anoikis. There are more than 15 subunits and 8 subunits, which pair with each other in different
combinations to generate a repertoire of over 20 different integrin receptors. These may other be selective for one or two
ligands or being promiscuous, binding multiple ligands. Similarly, the same ECM component may be recognized by one
individual integrin receptor or multiple receptors. Integrin expression is frequently altered in pathological conditions and
mutations in the INTG genes are associated with inheritable diseases. In cancer, integrins are fundamental in conferring
a more aggressive behaviour to malignant cells and are therefore considered attractive therapeutic targets. However,
thus far only one anti-integrin drug is registered for clinical application and its use is for the treatment of neurological
rather rather neoplastic diseases.
[Immunogen]
Recombinant integrin 6 subunit
 Cross reactivity 
Human
 Application 
Western blotting (1/250 to 1/500), Immunohistochemistry (1/150 to 1/200)



 IMAGE1



Immunolabeling of human adult skin

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Immunoblotting of sarcoma HT1080 whole-cell extracts

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Flow cytometry on A375 melanoma cells
 
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