Function : Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Tissue specificity : Expressed in brain. Very low levels detected in liver kidney, testis, and uterus.
Sequence similarities : Belongs to the transient receptor family. STrpC subfamily. Contains 2 ANK repeats.
Anti Mouse Trpc5 Polyclonal Antibody
Background
Application
| ELISA | WB | IHC | ICC |
|---|---|---|---|
| 1.0 μg/mL | 1.0-5.0 μg/mL | Not tested | Not tested |
| IP | FCM | IF | Neutralization |
| Not tested | Not tested | Not tested | Not tested |
| ELISA | WB | IHC | ICC |
|---|---|---|---|
| 1.0 μg/mL | Not tested | Not tested | Not tested |
| IP | FCM | IF | Neutralization |
| Not tested | Not tested | Not tested | Not tested |
Character
| Type | Polyclonal Antibody |
| Immunogen | Partial peptide of Mouse Trpc5 C-terminal region |
| Raised in | Rabbit |
| Source | Rabbit Serum |
| Purification notes | Antigen Affinity |
| Cross Reactivity | |
| Concentration | 0.25 mg/mL |
| Contents (Volume) | 25 μg (100 μL/vial) |
| Label | Unlabeled |
| Buffer | PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat] |
| Storage | Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided. |
<Reference>
1. Yoshida T, et al. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol. 2006 Nov;2(11):596-607. *Application Reference
2. Okada T, et al. Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem. 1998 Apr 24;273(17):10279-87.
