Function : Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Tissue specificity : Lung and brain. Post-translational modification: N-glycosylated.
Sequence similarities : Belongs to the transient receptor family. STrpC subfamily. Contains 3 ANK repeats.
Anti Mouse Trpc6 Polyclonal Antibody
Background
Application
| ELISA | WB | IHC | ICC |
|---|---|---|---|
| 1.0 μg/mL | Not tested | 5.0-10 μg/mL | 1.0-5.0 μg/mL |
| IP | FCM | IF | Neutralization |
| Not tested | Not tested | Not tested | Not tested |
Character
| Type | Polyclonal Antibody |
| Immunogen | Partial peptide of Mouse Trpc6 C-terminal |
| Raised in | Rabbit |
| Source | Rabbit Serum |
| Purification notes | Antigen Affinity |
| Cross Reactivity | |
| Concentration | 0.25 mg / mL |
| Contents (Volume) | 25 μg (100 μL / vial) |
| Label | Unlabeled |
| Buffer | PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat] |
| Storage | Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided. |
<Reference>
1. Inoue R, et al. The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res. 2001 Feb 16;88(3):325-32. *Application Reference.
