Function : Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Tissue specificity : Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver and spleen.
Sequence similarities : In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. Contains 1 alpha-type protein kinase domain.
Anti Mouse Trpm7 Polyclonal Antibody
Background
Application
| ELISA | WB | IHC | ICC |
|---|---|---|---|
| 1.0 μg/mL | Not tested | Not tested | Not tested |
| IP | FCM | IF | Neutralization |
| Not tested | Not tested | Not tested | Not tested |
Character
| Type | Polyclonal Antibody |
| Immunogen | Partial peptide of Mouse Trpm7 C-terminal region |
| Raised in | Rabbit |
| Source | Rabbit Serum |
| Purification notes | Antigen Affinity |
| Cross Reactivity | Human |
| Concentration | 0.25 mg/mL |
| Contents (Volume) | 25 μg (100 μL/vial) |
| Label | Unlabeled |
| Buffer | PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat] |
| Storage | Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided. |
<Reference>
1. Numata T, et al. TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells. Am J Physiol Cell Physiol. 2007 Jan;292(1):C460-7. *Application Reference
2. Hanano T, et al. Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci. 2004 Aug;95(4):403-19. *Application Reference
