| ELISA | WB | IHC | ICC |
|---|---|---|---|
| - | 1.0 | - | - |
| IP | FCM | IF | Neutralization |
| - | 1.0 | - | - |
[WB] CCR5 transfected 293T cell lysate
[FCM] CCR5 expressing 293 cells
<Summary>
#. Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
# Subcellular location: Cell membrane; Multi-pass membrane protein.
# Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
# Sequence similarities: Belongs to the G-protein coupled receptor 1 family
