Anti ƒ¿-Synuclein Antibodies


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Alpha-Synuclein, a 140-amino acid protein abundantly expressed in presynaptic terminals, is known as a component of intraneuronal or glial inclusions observed in cases of Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and Multiple system atrophy (MSA). Alpha-Synuclein is a natively unfolded protein, however, fibrillization or conformational change of Alpha-synuclein is central in the pathogenesis of Alpha-synucleinopathies. The amino-terminal region of Alpha-synuclein consists of seven imperfect repeats, each 11 amino acids in length, with the consensus sequence KTKEGV. The repeats partially overlap with a hydrophobic region (amino acids 61-95). The carboxy-terminal region (amino acids 96-140) is negatively charged. These antibodies are powerful tools for biochemical and IHC analyses of neurodegenerative diseases and for evaluation of conformational changes of Alpha-synuclein.

References

1)Masami Masuda, et al. Inhibition of a-synuclein fibril assembly by small molecules: A
FEBS Letters (2009) 583, 787-791. PMID 19183551
2) Motokuni Yonetani, et al. Conversion of wild-type alpha-synuclein into mutant-type fib
A30P mutant. Journal of Biological Chemistry (2009) 284, 7940-7950.
PMID 19164293

Product List

Product Name Cat# Quantity Price

Anti (α) Synuclein (1-10) (Rabbit)  DataSheet

CAC-TIP-SN-P01

50 UL ¥40,000
$534

Anti (α) Synuclein (11-20) (Rabbit)  DataSheet

CAC-TIP-SN-P02

50 UL ¥40,000
$534

Anti (α) Synuclein (21-30) (Rabbit)  DataSheet

CAC-TIP-SN-P03

50 UL ¥40,000
$534

Anti (α) Synuclein (31-40) (Rabbit)  DataSheet

CAC-TIP-SN-P04

50 UL ¥40,000
$534

Anti (α) Synuclein (41-50) (Rabbit)  DataSheet

CAC-TIP-SN-P05

50 UL ¥40,000
$534

Anti (α) Synuclein (51-60) (Rabbit)  DataSheet

CAC-TIP-SN-P06

50 UL ¥40,000
$534

Anti (α) Synuclein (61-70) (Rabbit)  DataSheet

CAC-TIP-SN-P07

50 UL ¥40,000
$534

Anti (α) Synuclein (75-91) (Rabbit)  DataSheet

CAC-TIP-SN-P08

50 UL ¥40,000
$534

Anti (α) Synuclein (131-140) (Rabbit)  DataSheet

CAC-TIP-SN-P09

50 UL ¥40,000
$534

Anti (α) Synuclein (9 antibodies set) (Rabbit)  DataSheet

CAC-TIP-SN-SET

9*10 UL ¥90,000
$1200

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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