Antibody for component of 26S proteasome

Anti Pad1 (S. pombe) Polyclonal Antibody


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Background

Schizosaccharomyces pombe Pad1, a 35 kDa protein, is a component of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Transcription factor Pap1 is controlled by the functional interaction between the positive regulator Pad1 and negative regulator Crm1. Both proteins are essential for cell viability and for the maintenance of chromosome structure. Pad1 is also responsible for resistance to staurosporine, and other drugs such as cycloheximide and caffeine.

Application

• Immunoblotting (dilution: 1/300~1/1000)
• IP

Optimal dilutions/concentrations should be determined by the end user.

References

1) Shimanuki M et al. gA novel essential fission yeast gene pad1+ positively regulates pap1+-dependent
transcription and is implicated in the maintenance of chromosome structure.h J Cell Sci 108: 569-579 (1995)
PMID: 7769002
2) Tatebe H and Yanagida M gCut8, essential for anaphase, controls localization of 26S proteasome, facilitating
destruction of cyclin and Cut2.h Curr Biol. 10:1329-1338 (2000) PMID: 11084332
3) Takeda K and Yanagida M gRegulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and
destruction of the sensor and anchor Cut8.h Cell 122:393-405 (2005) PMID: 16096059

Product List

Product Name Cat# Quantity Price

Anti Pad Schizosaccharomyces pombe  (Rabbit) Unlabeled DataSheet

BAM-63-133-EX

100 UL ¥35,000
$467

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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