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Anti NƒÃ-(carboxyethyl) lysine (CEL) monoclonal antibody


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Background

Nε-(carboxyethyl) lysine (CEL) is generated from protein modification by methylglyoxal (MG), which is enzymatically derived from the Embden-Meyerhof and polyol pathways, through the degradation of glyceraldehyde-3-phosphate (G3P) (Phillips and Thornalley, 1993). Mclellan et al.(McLellan et al., 1994) demonstrated that plasma MG Concentrations in insulin-dependent diabetic patients were 7-times higher than those of healthy individuals.
CAC_JWUM02_1.gif

<CML production pathway>
CAC_JWUM02_2.gif

Application

Western blotting, 1/200 to 1/400
Immunohistochemistry, 1/100 to 1/200
ELISA, 1/200 to 1/400

References
1) Nagai R., Fujiwara Y., Mera K., Yamagata K., Sakashita N., Takeya M. Immunochemical detection of Nε-(carboxyethyl)lysine using a specific antibody. J. Immunol. Methods 332, 112-120 (2008)

Product List

Product Name Cat# Quantity Price

Anti N(ε)-(carboxyethyl) lysine (CEL) (Mouse)  DataSheet

CAC-AGE-M02

100 UL ¥50,000
$667

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