Anti Chondromodulin-I Monoclonal Antibody


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Background

Chondromodiulin-1(ChM-1) is a 121-amino acid residue glycoprotein (25-kDa), which was initially identified as a cartilage-specific functional matrix component that stimulates the growth and matrix synthesis of primary cultured chondrocytes in vitro. ChM-1, subsquently, was found to inhibit th e proliferation of vascular endothelial cells as well as as tube morphogenesis in vitro.ChM-1 is highly expressed in the avascular zones of cartilage. Recently,
ChM-1 has been reported to be highly expressed in nomal cardiac valves but at markedly reduced levels in valvular heart disease and maintain cardiac valvular functon by preventing angiogenesis in vivo.

References

1)@Hiraki Y. et al.@Identification of Chondromodulin I as a novel endothelial cell growth inhibitor.@J.Biol.Chem. 271, 22657-62 (1996).
2) Hiraki Y. et al. Molecular cloning of human chondromodulin-I , a cartilage derived growth modulating factor, and its expression in Chinese hamster ovary cells. Eur. J.Biochem. 260, 869-78 (1999).
3) Nakamichi Y. et al. Chondromodulin-I is a bone remodeling factor Mol.Cell.Biol. 23, 636-44 (2003).
4) Yoshioka Y. et al. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nature Med. 12, 1151-59 (2006).
5) Miura S.et al. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-1, a cartilage-derived angiogenesis inhibitor. Exp.Cell.Res. 316, 775-788 (2010)

Product List

Product Name Cat# Quantity Price

Anti Chondromodulin-I, Human (Mouse) Unlabeled DataSheet

CAC-TCS-001

100 UG ¥60,000
$800

Anti Chondromodulin-I, Human (Mouse) Unlabeled DataSheet

CAC-TCS-002

100 UG ¥60,000
$800

Anti Chondromodulin-I, Human (Mouse) Unlabeled DataSheet

CAC-TCS-003

100 UG ¥60,000
$800

Anti Chondromodulin-I, Human (Mouse) Unlabeled DataSheet

CAC-TCS-004

100 UG ¥60,000
$800

Anti Chondromodulin-I, Human (Mouse) Unlabeled DataSheet

CAC-TCS-005

100 UG ¥60,000
$800

Anti Chondromodulin-I, Bovine (Mouse) Unlabeled DataSheet

CAC-TCS-006

100 UG ¥60,000
$800

Anti Chondromodulin-I, Bovine (Mouse) Unlabeled DataSheet

CAC-TCS-007

100 UG ¥60,000
$800

Anti Chondromodulin-I, Bovine (Mouse) Unlabeled DataSheet

CAC-TCS-008

100 UG ¥60,000
$800

Anti Chondromodulin-I, Bovine (Mouse) Unlabeled DataSheet

CAC-TCS-009

100 UG ¥60,000
$800

Anti Chondromodulin-I, Bovine (Mouse) Unlabeled DataSheet

CAC-TCS-010

100 UG ¥60,000
$800

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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