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Powerful tools in studying DNA damage and its biological effects

Antibodies against Nucleotide excision repair (NER)


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Anti XPA monoclonal antibody [Clone : A-2]
Anti XPF monoclonal antibody [Clone : 19-16]
Anti XPG monoclonal antibody [Clone : G-26]
Anti ERCC1 monoclonal antibody [Clone : E1-44]

 

Monoclonal Antibodies against DNA DamagePDF

 

Background

Nucleotide excision repair (NER) is a major repair system for removing a variety of DNA lesions including UV-induced cyclobutane pyrimidine dimer and (6-4) photoproduct as well as chemical-induced bulky base adducts. Defects in the NER system give rise to xeroderma pigmentosum (XP), an autosomal recessive disease characterized by a predisposition to skin cancer and in some cases neurological abnormalities. The early process of human NER, from damage recognition to dual incision (removal of damage-containing oligonucleotides), is accomplished by six core NER factors, XPC-RAD23B, TFIIH, XPA, RPA, ERCC1-XPF and XPG in vitro.

Application

<Western blotting>

Product List

Anti XPA monoclonal antibody [Clone : A-2]

# XPA has an ability to bind to DNA with some preference to damaged DNA and interacts with most of other NER factors. XPA appears to be involved in a proper assembly of preincision complex and verification of damaged DNA strand.


Product Name Cat# Quantity Price

Anti XPA (Mouse) Unlabeled DataSheet

CAC-KUP-TM-M01

100 UL ¥50,000
$667

Anti XPF monoclonal antibody [Clone : 19-16]

# XPF harbors a nuclease domain and forms a stable complex with ERCC1. The ERCC1-XPF complex has a unique ability to make a nick on the DNA strand which makes the transition from duplex to single-stranded DNA in the 5' to 3' direction. In the NER process, ERCC1-XPF is responsible for 5'-incision at a dual incision step.

Product Name Cat# Quantity Price

Anti XPF (Mouse) Unlabeled DataSheet

CAC-KUP-TM-M02

100 UL ¥50,000
$667

Anti XPG monoclonal antibody [Clone : G-26]

# XPG is a structure-specific endonuclease with an opposite polarity to ERCC1-XPF and makes a nick on the DNA strand which makes the transition from single-stranded to duplex DNA in the 5' to 3' direction. In the NER process, XPG is responsible for 3'-incision at a dual incision step.

Product Name Cat# Quantity Price

Anti XPG (Mouse) Unlabeled DataSheet

CAC-KUP-TM-M03

100 UL ¥50,000
$667

Anti ERCC1 monoclonal antibody [Clone : E1-44]

# ERCC1 forms a stable complex with XPF and the heterodimer has an ability to make a nick on the DNA strand which makes the transition from duplex to single-stranded DNA in the 5' to 3' direction. In the NER process, ERCC1-XPF complex is responsible for 5'-incision at a dual incision step.

Product Name Cat# Quantity Price

Anti ERCC1 (Mouse) Unlabeled DataSheet

CAC-KUP-TM-M04

100 UL ¥50,000
$667

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