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Anti Atg7 (Clone: ATG7E2) Monoclonal antibody


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Background

Autophagy is an evolutionaly conserved machinery, in which autophagosome fuses with lysosome and degrades bulk cytoplasmic contents. Autophagy is involved in many physiological processes such as development, infection, cancer, and neurodegenerative diseases. ATG (autophagy-related) genes were identified by genetic screening in yeast. Atg7 acts as an E1-like enzyme in both Atg12 and Atg8 ubiquitin-like conjugation systems. Atg7 transfers Atg12 to an E2-like enzyme Atg10, and conjugates Atg12 to Atg5. In the other hand, Atg7 transfers Atg8 to another E2-like enzyme Atg3, and conjugates Atg8 to phosphatidylethanolamine. Many of these ATG genes are conserved also in mammals. Atg7 deficient neonates die soon after birth as they cannot endure perineonatal starvation. Conditional deletion of Atg7 in nerves system results in neurodegeneration with ubiquitin containing aggregates.

Application


Sample : Lysate of Hera Cells

Reference

1) Klionsky and Emr, 2000, Science, 290, 1717-21
2) Mizushima et al., 2008, Nature, 451, 1069-75
3) Tsukada and Ohsumi, 1993, FEBS Lett, 333, 169-74
4) Mizushima et al., 1998, Nature, 395, 395-8
5) Komatsu et al., 2005, J Cell Biol, 169, 425-34
6) Komatsu et al., 2006, Nature, 441, 880-4

Product List

Product Name Cat# Quantity Price

Anti ATG7, Human (Mouse Mono) Unlabeled DataSheet

CAC-CTB-AT7-M01

50 UG ¥50,000
$667

Product Name Cat# Quantity Price

Anti Atg5, Human (Rabbit)  DataSheet

CAC-TMD-PH-AT5

100 UL N/A

Anti ATG7, Human (Mouse Mono) Unlabeled DataSheet

CAC-CTB-AT7-M01

50 UG ¥50,000
$667

Anti Atg12, Mouse (Rabbit)  DataSheet

CAC-TMD-PH-AT12

100 UL N/A

Anti Atg16L, Mouse (Rabbit)  DataSheet

CAC-TMD-PH-AT16L

100 UL N/A

Anti LC3, Human (Mouse) Unlabeled DataSheet

CAC-CTB-LC3-1-50

50 UG ¥50,000
$667

Anti LC3, Human (Mouse) Unlabeled DataSheet

CAC-CTB-LC3-2-IC

50 UG ¥60,000
$800

Anti BIF1, Human (Mouse) Unlabeled DataSheet

CAC-CTB-BF-M01-W

50 UG ¥50,000
$667

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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