For research on allergies.

Allergic disease antibodies


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Background

The Th2 subset of CD4+ T helper cells play a key role in controlling immunity to extracellular parasites and allergic inflammatory responses, in large part due to their secretion of the cytokine IL-13. IL-13 plays a major role in inducing the physiologic changes associated with allergic inflammation. Gene expression microarray profiling analysis has identified squamous cell cancer antigen (SCCA) as an IL-13 inflammation-induced gene in tracheal epithelial cells and keratinocytes whose expression involves IL-13.  SCCA expression is increased in asthmatic bronchiale and atopic dermatitis skin. Two isoforms of SCCA are known: SCCA1 and SCCA2. These antibodies described here will be useful for additional allergy related research. 

< Immunohistochemistry >

Anti human SCCA monoclonal antibodyiCat#FCAC-SU-IZ-P04jImmunohistochemical staining of squamous cell carcinoma antigen (SCCA) in atopic dermatitis (AD) skin, and involved skin of AD patients with or without 200-fold diluted anti-SCCA monoclonal antibody is depicted. The signal of the immunoreacted horseradish peroxidase was developed by the diamino benzidine solution (brown colour).

References

> Shoichiro Ohta, et al. 2012. The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing atopic dermatitis. Ann Clin Biochem. 49: 277?284.

> Y. Sakata, et al. 2004. Characterization of novel squamous cell carcinoma antigen-related molecules in mice. Biochem Biophys Res Commun. 324(4):1340-1345.

> K. Mitsuishi, et al. 2005. The squamous cell carcinoma antigens as relevant biomarkers of atopic dermatitis. Clin Exp Allergy 35:1327?1333

> Chiho Goda, et al. 2006. Involvement of IL-32 in activation-induced cell death in T cells. Int Immunol 18(2):233-240

Product List

Product Name Cat# Quantity Price

Anti SCCA1, Human (Rat) Unlabeled DataSheet

CAC-SU-IZ-M08

100 UL ¥50,000
$667

Anti SCCA2, Human (Rat) Unlabeled DataSheet

CAC-SU-IZ-M01

100 UL ¥50,000
$667

Anti SCCA1/SCCA2, Human (Rat) Unlabeled DataSheet

CAC-SU-IZ-M07

100 UL ¥50,000
$667

Anti SCCA, Human (Rabbit) Unlabeled DataSheet

CAC-SU-IZ-P04

100 UL ¥50,000
$667

Anti IL13Ra D1 domain, Human (Rat)  DataSheet

CAC-SU-IZ-M03

100 UL ¥50,000
$667

Anti IL13Ra D1 domain, Human (Rat)  DataSheet

CAC-SU-IZ-M04

100 UL ¥50,000
$667

Anti IL13 Receptor α1, Human (Rat)  DataSheet

CAC-SU-IZ-M05

100 UL ¥50,000
$667

Product Name Cat# Quantity Price

Anti RIG-I, Mouse (Rat) Unlabeled DataSheet

CAC-SU-IZ-M02

100 UL ¥50,000
$667

Anti EGFP (Rabbit) Unlabeled DataSheet

CAC-SU-IZ-P01

100 UL ¥50,000
$667

Anti IL32, Human (Rabbit)  DataSheet

CAC-SU-IZ-P02

100 UL ¥50,000
$667

Anti SQN-5 (serpinb3a), Mouse (Rabbit) Unlabeled DataSheet

CAC-SU-IZ-P03

100 UL ¥50,000
$667

Anti Filamin A, Mouse (Rabbit) Unlabeled DataSheet

CAC-SU-IZ-P05

100 UL ¥50,000
$667

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.