Antibody for modification of histone

Anti Histone H3 S10ph Monoclonal Antibody


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Background

Post-translation modifications of histones modulate the accessibility and transcriptional competence of specific chromatin regions within the eukaryotic genome. Phosphorylation of histone H3 is unique in the sense that it associates on one hand with open chromatin during gene activation and marks on the other hand highly condensed chromatin during mitosis.

Application

E Western blotting: 1/2500 
E Immunocytochemistry: 1/5000

Other applications have not been tested.
Optimal dilutions/concentrations should be determined by the end user.

CAC_CE034A_2 Western blot analysis of HeLa whole cell extracts using Histone H3 S10ph antibody, 6G8B7.
CAC_CE034A_3
Immunocytochemical analysis of HeLa Cell using Histone H3 S10ph antibody, 6G8B7.

 

The composition of Histone H3 peptides and the reactivity of Histone H3 S10ph antibody, 6G8B7.

CAC_CE034A_1
H3 peptide               1   ARTKQTARKS   TGGKAPRKQ      19
H3 S10ph peptide@@@1   ARTKQTARKSphTGGKAPRKQ      19
H3 S28ph peptide     21      ATKAARKSphAPATGGVKKPH   39
References

1) Strahl and Allis, (2000) Nature 403, 41-45.

Product List

Product Name Cat# Quantity Price

Anti Histone H3 S10ph, Human (Rat)  DataSheet

CAC-CE-034A

100 UL ¥58,000
$774

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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