Anti Neurocan peptides Polyclonal Antibody


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Background

Neurocan is a nervous tissue-unique, secretory proteoglycan that carries predominantly chondroitin sulfate side chains. Its expression gradually decreases with the nervous tissue development. In the immature brain, neurocan exists in a full-length form with a 240 kDa-core glycoprotein, whereas it exists totally in proteolytic fragments of the NH2-terminal half (neurocan-N) with a 130 kDa-core glycopeptide and the COOH-terminal half (neurocan-C) with a 150 kDa-core glycopeptide. Neurocan is implicated in the neural network formation, and is a susceptibility factor for bipolar disorder. This proteoglycan is upregulated in the lesion site of the central nervous system, and is a major component of the glial scar. In addition, neurocan-N, not neurocan-C, is detectable in the perineuronal nets of some neurons. This antibody recognizes effectively neurocan-N as well as the full-length neurocan.

Application

Western blotting: 1/200
Immunohistochemistry (Paraffin): 1/200

Other applications have not been tested.
Optimal dilutions/concentrations should be determined by the end user.

Cross reactivity

Rat, Mouse

References

1) Matsui, F., Watanabe, E., & Oohira, A., Immunological identification of two proteglycan
fragments derived from neurocan, a brain-specific chondroitin sulfate proteoglycan, (1994)
Neurochem. Int., 25, 425-431.
2) Oohira, A., Matsui, F., Tokita, Y., Yamauchi, S., & Aono, S., Molecular interactions of
neural chondroitin sulfate proteoglycans in the brain development, (2000) Arch. Biochem.
Biophys., 374, 24-34.

Product List

Product Name Cat# Quantity Price

Anti Neurocan Peptides, Rat (Rabbit) Unlabeled DataSheet

CAC-NU-07-005

200 UL ¥50,000
$667

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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