Anti COMP Fragment (2127F5)


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[Cartilage Oligomeric Matrix Protein ]

Background

COMP - Cartilage oligomeric matrix protein - belongs to the thrombospondin family of ECM components and is a prominent multidomain glycoprotein of cartilage, accounting for up to 1% of the wet weight of articular tissues and having an approximate Mr of 97 kDa [1-4]. COMP may also be found in tendon, bone (i.e. osteoblasts), ligament, certain smooth muscles and synovium and more recently has been discovered to be a primary constituents of the dermal ECM [5]. In the ECM COMP is present in a pentameric, disulfide-bonded complex of an Mr of about 550 kDa, often seen associated with the chondrocyte cell surface [3, 5]..

Application Example

Left panel: Western blotting on recombinant COMP produced in HEK293 cells after SDS-PAGE under reducing conditions on 8% gels. Lanes 1 and 2 from left show secreted and cell-bound COMP, whereas the two adjacent lanes show the controls. Right panels: immunohistochemical stainings of human articular cartilage at lower (left) and higher magnification (right).

References

1) Oldberg A, et all., J Biol Chem. 1992 Nov 5;267(31):22346-50. PMID: 1429587
2) Hedbom E, et all., J Biol Chem. 1992 Mar 25;267(9):6132-6.. PMID: 1556121
3) Morgelin M, et all., J Biol Chem. 1992 Mar 25;267(9):6137-41.PMID: 1556122
4) Cesare PE, et all., J Orthop Res. 1995 May;13(3):422-8.. PMID: 7602403
5) Agarwal P, et all., J Biol Chem. 2012 Jun 29;287(27):22549-59. PMID: 22573329

Product List

Product Name Cat# Quantity Price

Anti COMP Fragment (2127F5), Human (Mouse)  DataSheet

CAC-PRPG-CPF-M02

2 ML ¥55,000
$734

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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