Obesity and Metabolic Syndrome Related Antibody

Anti Human PPARγ Polyclonal Antibody


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Background

PPARs (peroxisome proliferator-activated receptors) are a family of transcription factors belonging to the nuclear hormone receptor superfamily. Widely expressed in vertebrates, PPARs play critical roles in metabolism and differentiation of a number of cell types. The PPARγ subtype was originally identified as a factor binding to a fatty acid specific enhancer of the aP2 gene. PPAR-γ actions are mediated by three isoforms resulting from alternative promoter selection and alternative splicing. PPAR-γ1 is widely expressed while PPAR-γ2 expression is restricted to adipose tissue and PPAR-γ3 expression is restricted to adipose tissue, macrophage, and colon. PPARγ participates in adipose cell differentiation and energy storage (Ref.1). Recently, these roles of PPARγ have focused attention on PPARγ as a target of the anti-diabetic thiazolidinedione class of drugs (Ref.2).

Application

• Western blotting: 1.0µg/ml

Package Size: 100µg (400µL/vial)
Format: Rabbit polyclonal antibody 0.25mg/mL
Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage: Store below -20ºC. 
Once thawed, store at 4ºC. Repeated freeze-thaw cycles should be avoided.
Purification method: This antibody was prepared from the serum of a rabbit immunized with a partial peptide representing the C-terminal domain of Human PPARγ and purified by peptide affinity chromatography
References

1 Auwerx J. et al.:
PPAR-gamma: a thrifty transcription factor. Nucl Recept Signal. 2003;1:e006.
Nucl Recept Signal. 2003;1:e006.
2 Kubota N. et al. :
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.
Mol Cell. 1999 Oct;4(4):597-609.

Product List

Product Name Cat# Quantity Price

Anti PPAR γ, Human (Rabbit) Unlabeled DataSheet

KAL-KG113

100 UG ¥39,000
$520

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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