Anti Human ABCG2 Polyclonal Antibody


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HGNC [ 74 ]

Application

ELISA WB IHC ICC
Not tested 1.0 Not tested Not tested
IP FCM IF Neutralization
Not tested 1.0 Not tested Not tested

(μg/mL)


[WB] ABCG2 transfected 293T cell lysate


[FCM] ABCG2 expressing 293 cells

 

< UniPlot Summary>
#@Function : Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-toblood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
#  Subcellular location : Cell membrane; Multi-pass membrane protein.
#  Tissue specificity : Highly expressed in placenta. Low expression in small intestine, liver and colon.
#  Sequence similarities Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Contains 1 ABC transmembrane type-2 domain. Contains 1 ABC transporter domain.

Character

Type Polyclonal Antibody
Immunogen Recombinant protein of full length Human ABCG2
Raised in mouse
Source Mouse Serum
Purification Protein A purified
Cross Reactivity  
Concentration 0.5 mg/mL
ContentsiVolumej 50μg /100μL)
Label Unlabeled
Buffer PBS, pH 7.2
Storage Store at - 20Ž long term, store at 4Ž short term. Avoid repeated freeze-thaw cycles.

<Reference>
1. Allikmets R., et al. "A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance." Cancer Res. 58:5337-5339(1998)
2. Doyle L.A., et al. "A multidrug resistance transporter from human MCF-7 breast cancer cells." Proc. Natl. Acad. Sci. U.S.A. 95:15665-15670(1998)
3. Doyle L.A., et al. Erratum. Proc. Natl. Acad. Sci. U.S.A. 96:2569-2569(1999)

Product List

Product Name Cat# Quantity Price

Anti ABCG2, Human (Mouse) Unlabeled DataSheet

KAL-KB483

50 UG N/A

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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