Anti Human LRP1 Polyclonal Antibody


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Application

ELISA WB IHC ICC
- 1 3 -
IP FCM IF Neutralization
- - 10 -

(μg/mL)


[WB] LRP1 transfected 293T cell lysate
 

[IHC] Paraffin embedded human endometrium tissue

[IF] HeLa cell

 

< UniPlot Summary>
#@Function // Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their      endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
#  Tissue specificity // Most abundant in liver, brain and lung.
#  Sequence similarities// Belongs to the LDLR family. Contains 22 EGF-like domains. Contains 31 LDL-receptor class A domains. Contains 34 LDL-receptor class B repeats.

Character

Type Polyclonal Antibody
Immunogen Recombinant protein of full length Human LRP1
Raised in mouse
Source Mouse Serum
Purification Protein A purified
Cross Reactivity Human
Concentration 1 mg/mL
ContentsiVolumej 50μg /100μL)
Label Unlabeled
Buffer PBS, pH 7.2
Storage Store at - 20Ž long term, store at 4Ž short term. Avoid repeated freeze-thaw cycles.

<Reference>
1. Herz J., et al. "Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor." EMBO J. 7:4119-4127(1988)
2. Van Leuven F., et al. "Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein." Genomics 24:78-89(1994)
3. Van Leuven F., et al. "Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms." Genomics 52:138-144(1998)

Product List

Product Name Cat# Quantity Price

Anti LRP1, Human (Mouse) Unlabeled DataSheet

KAL-KB478

50 UG N/A
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