Anti Human GRHPR Monoclonal Antibody


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Application

ELISA WB IHC ICC
1.0 10-20 5.0-10 Not tested
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested

(µg/mL)


[IHC] Rat kidney tissue

<UniPlot Summary>
# Function // Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
# Catalytic activity // Glycolate + NADP+ = glyoxylate + NADPH. D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.
# Subunit structure // Homodimer.
# Tissue specificity // Ubiquitous. Most abundantly expressed in the liver.
# Involvement in disease // Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000] ; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.

Character

Type Monoclonal Antibody
Immunogen Partial peptide of Human GRHPR (C-terminal region, 227-236aa)
Raised in GANP® mouse
Source Serum-free medium
Purification Protein G purified
Cross Reactivity Human, Rat
Concentration 0.25 mg/mL
Contents(Volume) 50 ug(200 ul / vial )
Label Unlabeled
Buffer PBS [containing2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store at - 20Ž long term, store at 4Ž short term. Avoid repeated freeze-thaw cycles.

<Reference>
1. "Identification and expression of a cDNA for human hydroxypyruvate/glyoxylatereductase." Rumsby G. et al. Biochim. Biophys. Acta 1446:383-388(1999) [PubMed: 10524214] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT. Tissue: Liver.
2. "The gene encoding hydroxypyruvatereductase (GRHPR) is mutated in patients with primary hyperoxaluria type II." Cramer S.D. et al. Hum. Mol. Genet. 8:2063-2069(1999) [PubMed: 10484776] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INVOLVEMENT IN HP2. Tissue: Liver.
3. Liu B. et al. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Aorta.

This product is generated from GANP® mice

Product List

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“Anti Human GRHPR Monoclonal Antibody” also belongs to the following categories.