useful for the research of pathologic analysis in variegated ageing mechanisms

Anti Klotho Monoclonal Antibodies


print

Function

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1.
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Database links  SwissProt : Q9UEF7

<Reference>
1) Biochem Biophys Res Commun.2000 Jan 19;267(2):597-602.
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.
Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K, Nakamura K, Iida A, Anazawa H, Koh N, Iwano A, Imura A, Fujimori T, Kuro-o M, Hanai N, Takeshige K, Nabeshima Y.
2) J Biol Chem. 2004 Mar 12;279(11):9777-84.
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
Tohyama O, Imura A, Iwano A, Freund JN, Henrissat B, Fujimori T, Nabeshima Y.
3) FEBS Lett. 2004 May 7;565(1-3):143-7.
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.
Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T, Nabeshima Y.
4) Science2007 Jun 15;316(5831):1615-8.
alpha-Klotho as a regulator of calcium homeostasis.
Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T, Nabeshima Y.
5) Proc Natl Acad Sci U S A2008 Mar 4;105(9):3455-60.
A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism.
Brownstein CA, Adler F, Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y, Reyes-Mugica M, Carpenter TO, Lifton RP.

Product List

Anti Human klotho Monoclonal Antibody@(Clone No. KM2076)


Product Name Cat# Quantity Price

Anti Klotho, Human (Rat Mono) Unlabeled DataSheet

KAL-KO603

50 UG ¥55,000
$734

Anti Human klotho Monoclonal Antibody@(Clone No. KM2119)


Product Name Cat# Quantity Price

Anti Klotho, Human (Rat Mono) Unlabeled DataSheet

KAL-KO604

50 UG ¥55,000
$734

Anti Mouse klotho Monoclonal Antibody@(Clone No. Rink12)


Product Name Cat# Quantity Price

Anti Klotho, Mouse (Rat Mono) Unlabeled DataSheet

KAL-KO605

50 UG N/A

Anti Mouse klotho Monoclonal Antibody (Clone No. Rink14)


Product Name Cat# Quantity Price

Anti Klotho, Mouse (Rat Mono) Unlabeled DataSheet

KAL-KO606

50 UG N/A

“Anti Klotho Monoclonal Antibodies” also belongs to the following categories.