Anti Human NEDD4L Polyclonal Antibody


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Application

ELISA WB IHC ICC
- 1 - -
IP FCM IF Neutralization
- - - -

(µg/mL)

 


[WB] NEDD4L transfected 293T cell lysate

 

< UniPlot Summary>
# Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.
# Subcellular location: Cytoplasm.
# Tissue specificity: Ubiquitously expressed, with highest levels in prostate, pancreas and kidney.
# Sequence similarities: Contains 1 C2 domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.Contains 4 WW domains.

Character

Type Polyclonal Antibody
Immunogen Recombinant protein of full length Human NEDD4L
Raised in mouse
Source Mouse Serum
Purification Protein A purified
Cross Reactivity Human
Concentration 0.46 mg/mL
Contents (Volume) 50 μg
Label Unlabeled
Buffer PBS, pH 7.2
Storage Store at -20Ž long term, store at 4Ž short term. Avoid repeated freeze-thaw cycles.

<Reference>
1. Chen H., et al. "NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene." Eur. J. Hum. Genet. 9:922-930(2001)
2. Malbert-Colas L., et al. "Identification of new partners of the epithelial sodium channel alpha subunit." C. R. Biol. 326:615-624(2003)
3. Qi H., et al. "Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells." Mol. Cell. Endocrinol. 210:51-62(2003)

Product List

Product Name Cat# Quantity Price

Anti NEDD4L, Human (Mouse) Unlabeled DataSheet

KAL-KB521

50 UG N/A

Product Name Cat# Quantity Price

Anti CaM Kinase II Δ1/2/3/4, Rat (Rabbit) Unlabeled DataSheet

KAL-KY041

200 UG ¥49,000
$654

Anti Aldehyde Oxidase, Rat (Rabbit) Unlabeled DataSheet

KAL-KR063

25 UG ¥49,000
$654

Anti Adenosine Deaminase2, Chicken (Rabbit) Unlabeled DataSheet

KAL-KR081

25 UG ¥49,000
$654

Anti Indoleamine-2,3 dioxygenase / IDO, Mouse (Rabbit) Unlabeled DataSheet

KAL-KR101

150 UG ¥49,000
$654

Anti ATP1B3, Human (Mouse) Unlabeled DataSheet

KAL-KB465

50 UG N/A

Anti NEDD4L, Human (Mouse) Unlabeled DataSheet

KAL-KB521

50 UG N/A

Anti NUDT9, Human (Mouse) Unlabeled DataSheet

KAL-KB523

50 UG N/A

Anti ATP2C1, Human (Mouse) Unlabeled DataSheet

KAL-KB542

50 UG N/A

Anti PDCD8, Human (Mouse) Unlabeled DataSheet

KAL-KB543

50 UG N/A

Anti DDX11, Human (Mouse) Unlabeled DataSheet

KAL-KB545

50 UG N/A

Anti CYB5R3, Human (Mouse) Unlabeled DataSheet

KAL-KB547

50 UG N/A

Anti UQCRC2, Human (Mouse) Unlabeled DataSheet

KAL-KB556

50 UG N/A

Anti UQCRC1, Human (Mouse) Unlabeled DataSheet

KAL-KB557

50 UG N/A

Anti EME1, Human (Mouse) Unlabeled DataSheet

KAL-KB559

50 UG N/A

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



“Anti Human NEDD4L Polyclonal Antibody” also belongs to the following categories.