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Anti mouse Nr5a1 (Ad4BP/SF-1) Monoclonal Antibody


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Application

Recommended Antibody Dilutions
ELISA WB IHC ICC
1.0 1.0-5.0 5.0-10 10
IP FCM IF Neutralization
Not Tested Not Tested 10 Not Tested

(µg/mL)


Sample : mouse testis

<UniPlot Summary>
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate.

Character

Type Monoclonal Antibody
Immunogen Recombinalt protein of mouse Nr5a1 (full length)
Raised in Rat
Source Serum-free medium
Purification Protein G purified
Cross Reactivity Mouse
Concentration 0.25 mg/mL
Contents (Volume) 50μg (200μL/vial)
Label Unlabeled
Buffer PBS [containing2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store below – 20Ž. Once thawed, store at 4Ž. Repeated freeze-thaw cycles should be avoided.

<Reference>
1) Shima Y, et al: Mol. Endocrinol. (2008) 22:1633-1646
2) Yokoyama C, et al: HYBRIDOMA (2009) 28(2):113-119 (Application Reference)

Product List

Product Name Cat# Quantity Price

Anti Nr5a1 (Ad4BP/SF-1), Mouse (Rat Mono) Unlabeled DataSheet

KAL-KO610

50 UG ¥55,000
$734

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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