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Mebiol Gel Hydrogel Literature Citations and References


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Cell Culture and Tissue Regeneration

Research Field Publication Pubmed ID (PMID)
Stem Cells (human pluipotent stem cell (hPSC) line expansion and differentiation)
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation.
Lei Y, Schaffer DV. 
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5039-48. doi: 10.1073/pnas.1309408110. Epub 2013 Nov 18.PMID: 24248365
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation.Lei Y, Schaffer DV. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5039-48. doi: 10.1073/pnas.1309408110. Epub 2013 Nov 18.
 24248365
 Stem Cells (corneal limbal), review Towards the use of hydrogels in the treatment of limbal stem cell deficiency Bernice Wright, Shengli Mi, Che J. Connon Drug Discovery Today, Volume 18, Issues 1–2, January 2013, Pages 79-86 a  22846850
 Cell Culture (kidney cyst formation)  Mxi1 influences cyst formation in three-dimensional cell culture. YJ Yook, KH Yoo, SA Song, MJ Seo, JY Ko, BH Kim, EJ Lee, E Chang, YM Woo, and JH Park BMB Rep, Mar 2012; 45(3): 189-93.   22449707
 ROS Cell-Based Assay  Determination of Chronic Inflammatory States in Cancer Patients Using Assay of Reactive Oxygen Species Production by Neutrophils Yoko Suzuki, Satoshi Ohno, Ryuji Okuyama, Atsushi Aruga, Masakazu Yamamoto, Shigeki Miura, Hiroshi Yoshioka, Yuichi Mori, And Katsuhiko Suzuki Anticancer Res, Feb 2012; 32: 565 - 570.ROS Cell-Based Assay  22287746
 ROS Cell-Based Assay  Effect of Green Tea Extract on Reactive Oxygen Species Produced by Neutrophils from Cancer Patients Katsuhiko Suzuki, Satoshi Ohno, Yoko Suzuki, Yumiko Ohno, Ryuji Okuyama, Atsushi Aruga, Masakazu Yamamoto, Ken-O Ishihara, Tsutomu Nozaki, Shigeki Miura, Hiroshi Yoshioka, And Yuichi Mori Anticancer Res, Jun 2012; 32: 2369 - 2375.  22641677
 Stem Cell Culture, Regenerative Medicine  Application of a Thermo-Reversible Gelation Polymer, Mebiol Gel, for Stem Cell Culture and Regenerative Medicine Kataoka K and Huh N* 2010 Vol. 6 (1): p10-14 (2010) http://www.pubstemcell.com/monthly/006010200003.htm  
 Organ Culture  FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation. Hiramatsu R, Harikae K, Tsunekawa N, Kurohmaru M, Matsuo I, Kanai Y. Development. 2010 Jan;137(2):303-12. doi: 10.1242/dev.040519.  20040496
 Stem Cells (corneal limbal)  Ex vivo cultivation of corneal limbal epithelial cells in a thermoreversible polymer (Mebiol Gel) and their transplantation in rabbits: an animal model. G Sitalakshmi, B Sudha, HN Madhavan, S Vinay, S Krishnakumar, Y Mori, H Yoshioka, and S Abraham Tissue Eng Part A, Feb 2009; 15(2): 407-15.  18724830
 Stem Cell (corneal limbal)  Limbal Stem Cells: Application in Ocular Biomedicine Review Article Geeta K. Vemuganti, Anees Fatima, Soundarya Lakshmi Madhira, Surendra Basti, Virender S. Sangwan International Review of Cell and Molecular Biology, Volume 275, 2009, Pages 133-181   19491055
 Virus infection/replication system  3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV Hussein Hassan Aly, Kunitada Shimotohno, Makoto Hijikata Biochemical and Biophysical Research Communications, Volume 379, Issue 2, 6 February 2009, Pages 330-334  19103167
 Embryo Explant Culture  Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H. J Cell Biol. 2009 Jan 26;184(2):323-34. doi: 10.1083/jcb.200808044. Epub 2009 Jan 19.  19153222
Hepatocyte Transplantation  Intraperitoneal Transplantation Of Hepatocytes Embedded In Thermoreversible Gelation Polymer (Mebiol Gel) In Acute Liver Failure Rat Model. Parveen, A.A. Khan, S. Baskar, M.A. Habeeb, P. Ravindra Babu, A. Samuel, Y. Hiroshi, M. Yuichi, C.M. Habibullah Journal of Hepatology, Volume 48, Supplement 2, 2008, Page S71 http://hepatmon.com/?page=article&article_id=529  
Stem Cells (mesenchymal)  Chrondrogenic differentiation of human mesenchymal stem cells from umbilical cord blood in chemicially synthesized thermoreversible polymer. Kao, I, et al. Chinese J. Physiology, 51(4), 252-258 (2008)  17112629
Hepatocyte Culture  Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes. Hussein H. Aly, Koichi Watashi, Makoto Hijikata, Hiroyasu Kaneko, Yasutugu Takada, Hiroto Egawa, Shinji Uemoto, Kunitada Shimotohno Journal of Hepatology, Volume 46, Issue 1, January 2007, Pages 26-36   17287553
Stem Cell (Corneal Limbal) Cultivation of human corneal limbal stem cells in Mebiol gel--A thermo-reversible gelation polymer. B Sudha, HN Madhavan, G Sitalakshmi, J Malathi, S Krishnakumar, Y Mori, H Yoshioka, and S Abraham Indian J Med Res, Dec 2006; 124(6): 655-64  
 Tissue Engineering (Bone)  In vitro culture of chondrocytes in a novel thermoreversible gelation polymer scaffold containing growth factors. Yasuda A, Kojima K, Tinsley KW, Yoshioka H, Mori Y, Vacanti CA. Tissue Eng. 2006 May;12(5):1237-45.  16771637
Stem Cells (epithelial)  Isolation of epithelial stem cells from dermis by a three-dimensional culture system. Medina RJ, Kataoka K, Takaishi M, Miyazaki M, Huh NH. J Cell Biochem. 2006 May 1;98(1):174-84.  16408300
Stem Cells (Corneal Limbal)  Comparative Study on Growth Characteristics of Cadaveric Human Corneal Limbal Stem Cells in Mebiol Gel (a Synthetic Polymer) and on Human Amniotic Membrane. H.N. Madhavan, B. Sudha1, G. Sitalakshmi, S. KrishnaKumar, Y. Mori, H. Yoshioka and S. Abraham.Invest Ophthalmol Vis Sci 2006;47: E-Abstract 3033. 3033—B186  
Tissue Regeneration (Liver)  Thermoreversible gelation polymer induces the emergence of hepatic stem cells in the partially injured rat liver. Nagaya M, Kubota S, Suzuki N, Akashi K, Mitaka T.Hepatology. 2006 May;43(5):1053-62.  16628635
Virus Reproduction and Drug Screening Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b.Murakami K, Ishii K, Ishihara Y, Yoshizaki S, Tanaka K, Gotoh Y, Aizaki H, Kohara M, Yoshioka H, Mori Y, Manabe N, Shoji I, Sata T, Bartenschlager R, Matsuura Y, Miyamura T, Suzuki T.Virology. 2006 Aug 1;351(2):381-92. Epub 2006 May 6. 16678876
Embryo Culture Canonical Wnt Signaling and Its Antagonist Regulate Anterior-Posterior Axis Polarization by Guiding Cell Migration in Mouse Visceral Endoderm. Chiharu Kimura-Yoshida, Hiroshi Nakano, Daiji Okamura, Kazuki Nakao, Shigenobu Yonemura, Jose A. Belo, Shinichi Aizawa, Yasuhisa Matsui, Isao Matsuo Developmental Cell, Volume 9, Issue 5, November 2005, Pages 639-650 16256739
Evalulation of Cell Line Growth in Mebiol Gel  H.N. Madhavan, J. Malathi, Patricia Rinku Joseph, Mori Yuichi, Samuel JK Abraham and Hiroshi Yoshioka. A study on the growth of continuous culture cell lines embedded in Mebiol Gel., Current Science, 87(9), 1275~77(2004).  
Stem Cell Culture and Differentiation Gene expression profile of human mesenchymal stem cells during osteogenesis in three-dimensional thermoreversible gelation polymer. Hishikawa K, Miura S, Marumo T, Yoshioka H, Mori Y, Takato T, Fujita T. Biochem Biophys Res Commun. 2004 May 14;317(4):1103-7. 15094382
Liver Regeneration Evaluation of Thermoreversible gelation polymer for Regeneration of Focal Liver Injury. M. Nagaya, S. Kubota, N. Suzuki, M. Tadakoro, K. Akashi. Eur Surg Res, 36:95-103 (2004). 15007262
Spheroid Culture (Cancer) S. Tsukikawa, H. Matsuoka, Y. Kurahashi, Y. Konno, K. Satoh, R. Satoh, A. Isogai, K. Kimura, Y. Watanabe, S. Nakano, J. Hayashi, and S. Kubota. A new method to prepare multicellular spheroids in cancer cell lines using a thermo-reversible gelation polymer, Artifcial Organs, 27(7), 598 -604(2003). 12823414
Wound healing Wound Dressing of Newly Developed Thermo gelling Thermo reversible Hydro gel. H. Yoshioka, Y. Mori, S. Kubota , Jpn J Artif Organs, 27(2), 503 -506 (1998).(Japanese Publication- Abstract in English)  
Islet Transplantation In Vitro Studies on a New Method for Islet Micro encapsulation Using a Thermo reversible Gelation Polymer, N-Isopropylacrylamide-Based Copolymer. S. Shimizu, M. Yamazaki, S. Kubota, T. Ozasa, H. Moriya, K. Kobayashi, M. Mikami, Y. Mori and S. Yamaguchi. Artif Organs, Vol. 20, No.11 (1996). 8908335

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Mebiol Gel Non-Cell Culture Applications

Research Field Publication Pubmed ID (PMID)
Protein Crystallization Scaffold
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation.
Lei Y, Schaffer DV. 
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5039-48. doi: 10.1073/pnas.1309408110. Epub 2013 Nov 18.PMID: 24248365
see Sugiyama, et al., Cryst. Growth Des., 2013, 13 (5), pp 1899–1904
 
 Scaffold for DNA Electrophoresis and Recovery Separation and recovery of DNA fragments by electrophoresis through a thermoreversible hydrogel composed of poly(ethylene oxide) and poly(propylene oxide).Yoshioka H, Mori Y, Shimizu M. Anal Biochem. 2003 Dec 15;323(2):218-23.  14656528
 Cell sorting switch  On-Chip Cell Sorting System Using Laser-Induced Heating of a Thermoreversible Gelation Polymer to Control Flow Y. Shirasaki, J. Tanaka, H. Makazu, K. Tashiro, S. Shoji, S. Tsukita, T. Funatsu.Anal. Chem., 78, 695-701 (2006)   16448041
 Cell sorting switch  On-chip cell sorting system using laser-induced heating of a thermoreversible gelation polymer to control flow.Anal Chem. 2006 Feb 1;78(3):695-701.Shirasaki Y, Tanaka J, Makazu H, Tashiro K, Shoji S, Tsukita S, Funatsu T.  16448041
 Cell sorting switch  Microfluidic cell sorter with flow switching triggered by a sol–gel transition of a thermo-reversible gelation polymer.Kazuto Ozaki, Hirokazu Sugino, Yoshitaka Shirasaki, Tokihiko Aoki, Takahiro Arakawa, Takashi Funatsu, Shuichi Shoji Sensors and Actuators B: Chemical, Volume 150, Issue 1, 21 September 2010, Pages 449-455 http://www.sciencedirect.com/science/article/pii/S0925400510006143  
 DNA molecular Sorting  Microfluidic active sorting of DNA molecules labeled with single quantum dots using flow switching by a hydrogel sol–gel transition Mai Haneoka, Yoshitaka Shirasaki, Hirokazu Sugino, Tokihiko Aoki, Takahiro Arakawa, Kazuto Ozaki, Dong Hyun Yoon, Noriyuki Ishii, Ryo Iizuka, Shuichi Shoji, Takashi FunatsuSensors and Actuators B: Chemical, Volume 159, Issue 1, 28 November 2011, Pages 314-320 http://www.sciencedirect.com/science/article/pii/S0925400511005521  16292493
 Drug delivery  J Neurooncol. 2006 Mar;77(1):9-15.Novel drug delivery system using thermoreversible gelation polymer for malignant glioma.Arai T, Joki T, Akiyama M, Agawa M, Mori Y, Yoshioka H, Abe T. J Neurooncol. 2006 Mar;77(1):9-15.  16292493
 Drug delivery  Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes.Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, Carroll RS, Black PM.Anticancer Res. 2010 Apr;30(4):1057-64.  20530409
Cell Culture for drug screening Alternatives to Animal Testing and ExperimentationWakui et al. in vitro Thermoreversible Gel Disc Quantitative Assay of Rat Angiogenesis. AATEX 16(2), 59-65, 2011https://www.jstage.jst.go.jp/article/aatex/16/2/16_2_59/_pdf  

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Mebiol Gel Physical Properties

Research Field Publication Pubmed ID (PMID)
Physical Properties
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation.
Lei Y, Schaffer DV. 
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5039-48. doi: 10.1073/pnas.1309408110. Epub 2013 Nov 18.PMID: 24248365
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation.Lei Y, Schaffer DV. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5039-48. doi: 10.1073/pnas.1309408110. Epub 2013 Nov 18.
 24248365
 Physical Properties A synthetic hydrogel with thermoreversible gelation. II. : Effect of added salts  
 Physical Properties  H. Yoshioka, M. Mikami, Y. Mori, and E. Tsuchida. J. Macromol. Sci., A31(1), 121-125 (1994). http://www.tandfonline.com/doi/abs/10.1080/10601329409349723#.UvFzqtKE1NQ  
 Physical Properties  Thermoreversible gelation on heating and on cooling of an aqueous gelatin-poly(N-isopropylacrylamide) conjugate. , H. Yoshioka, Y. Mori, S. Tsukikawa, and S. Kubota, Polym. Adv. Tech., 9, 155-158 (1998). http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1581(199802)9:2%3C155::AID-PAT750%3E3.0.CO;2-G/abstract  
 Physical Properties  A Synthetic hydrogel with thermoreversible gelation. I. Preparation and rheological properties , H. Yoshioka, M. Mikami and Y. Mori. J.M.S- Pure Appl. Chem., A31(1), pp. 113-120 (1994). http://www.tandfonline.com/doi/abs/10.1080/10601329409349722#.UvFK1dKE1NQ  
 Physical Properties  Preparation of Poly (N-Isopropylacrylamide)-b-Poly(Ethylene Glycol) and Calorimetric Analysis of its Aqueous Solution , H. Yoshioka, M. Mikami and Y. Mori, J.M.S- Pure Appl. Chem., A31(1), pp. 109-112 (1994). http://www.tandfonline.com/doi/abs/10.1080/10601329409349721#.UvFLB9KE1NQ  
 Physical Properties  A synthetic hydrogel with thermoreversible gelation. III. : An NMR study of the Sol-Gel transition. H. Yoshioka, Y. Mori and James A. Cushman. Polym. Adv. Tech., 5, pp. 122-127 (1994). http://onlinelibrary.wiley.com/doi/10.1002/pat.1994.220050207/abstract  

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To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.