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Anti GM3 (M2590) Monoclonanl Ganglioside Antibody


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Background

Ganglioside GM3 is a major glycosphingolipid in the plasma membrane and is widely distributed in all types of animal cells. GM3 has been shown to participate in the pathological conditions of Insulin resistance, and to inhibit VEGF/VEGFR-2-mediated angiogenesis through direct interaction between GM3 and VEGFR-2. Moreover, GM3 serves as a common precursor for all other ganglioside series gangliosides and hematosides, so this antibody will be extremely useful for the analysis of the biological functions of acidic glycosphingolipids.


 

CLONE M2590

SOURCE

This monoclonal antibody is produced by a hybridoma which is a cell fusion 
of mouse myeloma (P3U1) and spleen cell from C57BL/6 mouse which 
immunized by melanoma cells from C57BL/6 mouse
This monoclonal antibody is produced by a hybridoma which is a cell fusion of mouse myeloma (P3U1) and spleen cell from C57BL/6 mouse which immunized by melanoma cells from C57BL/6 mouse 
CONCENTRATION 1mg/ml
FORMAT Purified Protein
ISOTYPE IgMκ
PRESENTATION Liquid in 10mM phosphate buffer with 0.15M NaCl , pH7.2, 0.1% Sodium Azide
STORAGE / HANDLING Maintain 4°C - 8°C for 1 or 2 months in undiluted aliquots (-20 °C for long term storage) Avoid repeated freeze/thaw cycles

 


References

(1) S.Nakabayashi, T.Saito, N.Shinohara, S.Okamoto, H.Tomioka, and M.Taniguchi; J. Invest. Dermatol., 83, 128-133 (1984)
(2) Y. Hirabayashi, M.Matusmoto, and M.Taniguchi, J. Biol.Chem., 260, 13328-13333 (1985)
(3) G.A.Nores, T.Dohi, M.Taniguchi, and S.Hakomori; J.Immnol., 139, 3171-3176 (1987)
(4) Zhiyun Wang, Zhonghui Sun, Adrienne V. Li, and Kevin J. Yarema; J. Biol. Chem., 281: 27016 - 27028 (2006)
(5) Kazuya Kabayama, Takashige Sato, Kumiko Saito, Nicoletta Loberto, Alessandro Prinetti, Sandro Sonnino, Masataka Kinjo, Yasuyuki Igarashi, and Jin-ichi Inokuchi; PNAS, 104: 13678 - 13683 (2007)
(6) Tae-Wook Chung, Seok-Jo Kim, Hee-Jung Choi, Keuk-Jun Kim, Mi-Jin Kim, Sung-Hoon Kim, Hyo-Jeong Lee, Jeong-Heon Ko, Young-Choon Lee, Akemi Suzuki, and Cheorl-Ho Kim; Glycobiology, 19: 229 - 239 (2009)

Product List

Product Name Cat# Quantity Price

Anti GM3 (Mouse)  DataSheet

NBT-M101-EX

0.5 ML ¥150,000
$2000

Anti GM3 (Mouse)  DataSheet

NBT-M102-EX

1 ML ¥166,000
$2214

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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