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Antibodies for Neurodegenerative Disease Research


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In rapid aging of society, neurodegenerative diseases such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease are widely-recognized as a serious problem that needs to be addressed. These unique antibodies offered exclusively by Cosmo Bio are powerful tools in advancing our understanding of neurodegenerative pathologies and mechanisms.
Antibodies for Neurodegenerative Disease Researche [PDF]

Anti 4R-tau antibody Anti C9orf72 antibodies

Anti phosphorylated TDP-43 antibodies Anti α-Synuclein Antibodies

Amyotrophic Lateral Sclerosis (ALS)-Related Products

Anti 4R-tau antibody

 

This anti-4R antibody recognizes 4-repeat tau (4R-tau) isoforms regardless of the deamidation at Asn279 and strongly stains 4R-tau isoforms in AD brain.

A: Immuno blot analysis of 6 human tau isoforms (3-repeat and 4-repeat) with anti-tau (T46) and anti-4R (CAC-TIP-4RT-P01).

B: Immuno staining of paraffin embedded section of cerebral cortex prepared from AD brain (pretreated with proteinase K and formic acid)


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Anti C9orf72 antibodies

Antibodies raised against dipeptide repeat sequences encoded by C9ORF72 expansions stain the p62-psositive inclusions in FTLD and motor neuron disease.

  Immunostaining of the cerebellum of C9orf72 case for poly-GA protein with anti-GA antibody (CAC-TIP-C9-P01) (By the courtesy of Drs Tada and Takahashi in Niigata Univ). 


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Anti phosphorylated TDP-43 antibodies

Phosphorylated TDP-43 accumulates in pathological inclusions in brains with FTLD-TDP, ALS, AD, DLB and other neurodegenerative diseases.

 

 
NCIs in dentate gyrus of FTLD-TDP MAb pS409/410 stains ubiquitin-positive inclusions in FTLD-TDP and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD and other related diseases. Immunoblot analysis of Sarkosyl-insoluble fractions from control, FTLD-TDP and ALS brains with or without protein phosphatase (PPase) treatment.


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Anti α-Synuclein Antibodies

Fine tune your α-synuclein research with these antibodies raised against linear epitopes scanning the human α-synuclein sequence.

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To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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