Anti-POGZ antibody, rabbit polyclonal


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Background

POGZ (pogo transposable element-derived protein with zinc finger domain; 1,410 aa, 155 kDa) plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 (HP1 alpha) it plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.

Application Examples

 

Fig.1 Western blot of POGZ. Lane 1: Crude extract of HeLa cells transfected with control siRNA Lane 2: Crude extract of HeLa cells transfected with POGZ siRNA The antibody was used at 1/1,000

Fig.2 Immuno-fluorescence staining of POGZ. Paraformaldehyde fixed HeLa cells were stained with Hoechst 33342 and anti-POGZ antibody. The antibody was used at 1/500 dilution. Scale bar, 10 um

Fig. 3 Immuno-fluorescence staining of POGD on chromosomes. Chromosome spreads were prepared from HeLa cells and stained with Hoechst 33342 and anti-POGZ antibody. The antibody was used at 1/500 dilution. Scale bar, 10 um

References

Nozawa R.S et al (2010) Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat. Cell Biol. 12:719-727 PubMed: 20562864

Product List

Product Name Cat# Quantity Price

Anti POGZ, Human (Rabbit)  DataSheet

BAM-70-112-EX

100 UL ¥35,000
$467

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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