Anti PHLDA3 monoclonal antibody


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Background

PHLDA3 (Pleckstrin homology-like domain family A member 3) is a small PH (Pleckstrin homology) domain-only protein (127 a.a. in human) that is highly conserved in vertebrates.Recently PHLDA3 was found to be a p53-regulated repressor of Akt (ref 2), hence it is speculated as a tumor suppressor.PHLDA3 also inhibits anchorage-independent cell growth.PHLDA3 gene is frequently lost in human lung endocrine tumors.
The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Application

1. Western blotting
2. Other applications were not tested.

<Western blotting was performed using the antibody 4B6 to detect PHLDA3 protein expression.>

PHLDA3 protein was induced by Ad-p53 in MDA-MB-468 cells (left).
PHLDA3 expression was inhibited by shRNA targeting PHLDA3 (right).

<Reference>
1. Frank,D. et al. (1999) “A novel pleckstrin homology-related gene family defined by Ip1/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.” Mamm. Genome 10:1150-1159.
2. Kawase,T. et al. (2009) "PH domain-only PHLDA3 is a novel p53-regulated repressor of Akt". Cell 136: 535-550.

Product List

Product Name Cat# Quantity Price

Anti PHLDA3, Human (Mouse)  DataSheet

BAM-71-195-EX

100 UG ¥34,500
$460

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To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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