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useful for the research of anxiety diseases, autism, and Alzheimer's disease.

Anti glyoxalase I (GLO1) Monoclonal antibody


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Background

Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer’s disease.
The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Application

1) Western blotting (~X 1,000)
2) Immunocytochemistry
3) ELISA


Western blotting
Samples are whole cell extracts. Mouse GLO1 shows a single band of 27 kDa while human and simian ones show29 kDa.


Immunofluorescent : HeLa cells

<Reference>
1. Chen,F. et al. (2004) "Role for glyoxalase I in Alzheimer’s disease.” Proc. Natl. Acad. Sci. USA 101: 7687–7692.
2. Junaid, M.A. et al. (2004) "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." Am J. Med. Genet. A. 131: 11–17.
3. Hovatta, I. et al. (2005) "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice" Nature 438: 662–666. 

Product List

Product Name Cat# Quantity Price

Anti Glyoxalase I, Mouse (Rat) Unlabeled DataSheet

BAM-74-001-EX

100 UG ¥34,500
$460

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