marker of cancer stem cells in neurogenic tumors

Anti Nestin Monoclonal antibody


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Background

Nestin is an intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian central nervous system (CNS) during development. Nestin is replaced in the adult organism by other intermediate filament proteins, however, it may be re-expressed under certain pathological conditions such as ischemia, inflammation, brain injury, and neoplastic transformation. Nestin has been detected in many kinds of tumors, especially in tumors derived from the CNS, therefore it is considered to be a marker for cancer stem cells in neurogenic tumors.
The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Application

1) Immunocytochemistry
2) IImmunohistochemistry


Primary culture of neural progenitor cells from mouse fetal brain stained with 7A3 (Left), stained with Hoechst (Center), and without staing (Right).

<Reference>
1. Hockfield, S., McKay, R.D. (1985) "Identification of major cell classes in the developing mammalian nervous system". J Neurosci. 5: 3310-3328.
2. Gilyarov, A.V. (2008) “Nestin in central nervous system cells” Neuroscience and Behavioral Physiology 38:165-169. 

Product List

Product Name Cat# Quantity Price

Anti Nestin, Mouse (Rat)  DataSheet

BAM-73-100EX

100 UG see also
# BAM-73100EX
Size 200

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