Anti HP1α/CBX5 polyclonal antibody


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Background

Heterochromatin protein 1 (HP1) is a major component of heterochromatin and play a role in assembly of various proteins on chromatin and gene silencing. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species. The HP1 family of proteins is encoded by a class of genes known as the chromobox (CBX) genes. In humans, HP1α is encoded by the Chromobox homolog 5 (CBX5) gene located on chromosome 12q13.13. HP1α has been observed to interact directly or indirectly with several non-histone proteins with a wide variety of functions (1).
The product is prepared by immunizing rabbit with the synthetic peptide CEDAENKEKETAKS corresponding to the amino acid sequence 179-191 of human HP1α and by affinity purification with the peptide. The antiserum was prepared by the direction of Prof. T. Haraguchi.

Application

1) Western blotting (1/1000 ~ 1/3000)
2) Immunofluoresece staining (1/200 ~ 1/1000)


Western blotting.
Lane 1 Crude extract of MCF7 cells.
The antiserum was diluted 1000 fold before use.

<Reference>
1. Lomberk G et al. Genome Biol. 7, 228 (2006), review
2. Kametaka A et al. Genes Cells 7, 1231 (2002)
3. Wang F et al. Mol. Cell. Biol. 26, 4028 (2006)

Product List

Product Name Cat# Quantity Price

Anti HP1 (α) /CBX5, Human (Rabbit)  DataSheet

BAM-70-221-EX

50 UG ¥21,000
$280

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