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Anti Sup35/PSI+ (S.cerevisiae) polyclonal antibody


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Background

Sup35 protein of S. cerevisiae is the translation termination factor eRF3. The altered conformation of this protein generates the [PSI+] prion phenotype (1). In this state, a dominant cytoplasmically inherited protein aggregates are formed which sequester the normal function of Sup35 thereby nonsense suppressor phenotype is created (2). The molecular chaperon Hsp104 is necessary for the formation and maintenance of the aggregates (3, 4).

Data Link SGD SUP35/YDR172W

Application

1) Western blotting (1,000~2,000 fold dilution).
2) Not tested for other applications.

< Specification >
Reacts with Human and mammalian Rad51 protein

< Reference >
1. Paushkin, S.V. et al. “Propagation of the yeast prion-like PSI+ determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.” EMBO Journal 15, 3127-3134 (1996) PMID: 8670813
2. Salnikova, A.B. et al. “Nonsense suppression in yeast cells overproducing Sup35 (eRF3) is caused by its non-heritable amyloids.” J.Biol.Chem. 280, 8808-8812 (2005). PMID: 15618222
3. Chernoff, Y.O. et al. “Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].” Science 268,880-884 (1995) PMID: 7754373
4. Kimura,Y. et al. “The role of pre-existing aggregates in Hsp104- dependent polyglutamine aggregate formation and epigenetic change of yeast prions.” Genes to Cells 9, 685-696 (2004) PMID: 15298677

Product List

Product Name Cat# Quantity Price

Anti Sup35/PSI+ Saccharomyces cerevisiae  (Rabbit) Unlabeled DataSheet

BAM-62-300-EX

100 UL ¥42,100
$562

Related Antibodies


Product Name Cat# Quantity Price

Anti Sup35/PSI+ Saccharomyces cerevisiae  (Rabbit) Unlabeled DataSheet

BAM-62-300-EX

100 UL ¥42,100
$562

Anti Rnq1 Saccharomyces cerevisiae  (Rabbit) Unlabeled DataSheet

BAM-62-301-EX

100 UL ¥42,100
$562

Anti Cdc37 Saccharomyces cerevisiae  (Rabbit)  DataSheet

BAM-62-302-EX

100 UL ¥42,100
$562

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