useful for evaluation of cellular or animal models of TDP-43 proteinopathy.

Anti Phosphorylated TDP-43 Antibodies


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Background

TDP-43, a heterogeneous nuclear RNA binding protein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.

Anti phospho TDP-43 Mouse Monoclonal Antibody (pS409/410-1)

Antigen F CMDSKS(p)S(p)GWGM, S(p):phosphoserine 409/410

NCIs in dentate gyrus of FTLD-U
MAb pS409/410 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD or other related diseases by immunohistochemistry.

Catalog No.: CAC-TIP-PTD-M01

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Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS409/410-1)

Antigen : CMDSKS(p)S(p)GWGM, S(p):phosphoserine 409/410

NCIs in dentate gyrus of FTLD-U
pS409/410-1 sometimes stained ghost tangles and dot-like structures (granulovacuolar degeneration) in the hippocampal and other regions of brains with AD or other related diseases. For this reason, we recommend pS409/410-2 or mAb pS409/410 for immunohisochemistry of human tissues.

Catalog No.: CAC-TIP-PTD-P01

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Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS409/410-2)

Antigen : CMDSKS(p)S(p)GWGM, S(p):phosphoserine 409/410

NCIs in dentate gyrus of FTLD-U
pS409/410-2 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD or other related diseases.

Catalog No.: CAC-TIP-PTD-P02

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Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS409)

Antigen : CMDSKS(p)SGWGM, S(p):phosphoserine 409

NCIs and DNs in dentate gyrus of FTLD-U

Catalog No.: CAC-TIP-PTD-P03

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Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS410)

Antigen : CMDSKSS(p)GWGM, S(p):phosphoserine 410

NCIs and DNs in dentate gyrus of FTLD-U

Catalog No.: CAC-TIP-PTD-P04

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Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS403/404)

Antigen : NGGFGS(p)S(p)MDSKC, S(p):phosphoserine 403/404

NCIs in dentate gyrus of FTLD-U
pS403/404 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This stains granulovacuolar degeneration in some cases of AD or other related diseases only very weakly.

Catalog No.: CAC-TIP-PTD-P05

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Product List


Product Name Cat# Quantity Price

Anti TDP-43, phospho Ser409/410, Human (Mouse) Unlabeled DataSheet

CAC-TIP-PTD-M01

50 UL ¥50,000
$667

Anti TDP-43, phospho Ser409/410-1, Human (Rabbit) Unlabeled DataSheet

CAC-TIP-PTD-P01

100 UL N/A

Anti TDP-43, phospho Ser409/410-2, Human (Rabbit) Unlabeled DataSheet

CAC-TIP-PTD-P02

100 UL ¥50,000
$667

Anti TDP-43, phospho Ser409, Human (Rabbit) Unlabeled DataSheet

CAC-TIP-PTD-P03

100 UL ¥50,000
$667

Anti TDP-43, phospho Ser410, Human (Rabbit) Unlabeled DataSheet

CAC-TIP-PTD-P04

100 UL ¥50,000
$667

Anti TDP-43, phospho Ser403/404, Human (Rabbit) Unlabeled DataSheet

CAC-TIP-PTD-P05

100 UL ¥50,000
$667

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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