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Monoclonal Antibodies to Transcription Factors and Nuclear DNA Binding Proteins

Anti Stat6 [STAT6B, STAT6C, D12S1644, IL-4-STAT] monoclonal antibody (clone : STAAD23A)


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Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [NCBI Entrez Gene Summary]

Application

[Western Blot]
Detection of human STAT6 by Western blot. Samples: Whole cell lysate (25 μg) from HeLa cells. [Lot No. STAAD23A-2]

Predicted molecular weight: 94 kDa

Western_blot_protocolPDF

 

[Flow cytometry]
HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-STAT6 mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. STAAD23A-2]

Flow cytometry protocolPDF

 

[Immunocytochemistry]
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-STAT6 mAb. [Lot No. STAAD23A-2]

Immunocytochemistry protocolPDF

Product List

Product Name Cat# Quantity Price

Anti STAT6, Human (Mouse) Unlabeled DataSheet

CBX-CBX00238

100 UG ¥39,000
$520

“Anti Stat6 [STAT6B, STAT6C, D12S1644, IL-4-STAT] monoclonal antibody (clone : STAAD23A)” also belongs to the following categories.