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Monoclonal Antibodies to Transcription Factors and Nuclear DNA Binding Proteins

Anti E2F1 [E2F-1, RBP3] monoclonal antibody (clone : 658C2a)


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Background

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [NCBI Entrez Gene Summary]

Application

[Western Blot]
Western blot analysis of immunized recombinant protein, using anti-E2F1 monoclonal antibody.

Western_blot_protocolPDF

Product List

Product Name Cat# Quantity Price

Anti E2F1, Human (Mouse) Unlabeled DataSheet

CBX-CBX00440

100 UG ¥39,000
$520

“Anti E2F1 [E2F-1, RBP3] monoclonal antibody (clone : 658C2a)” also belongs to the following categories.