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Monoclonal Antibodies to Transcription Factors and Nuclear DNA Binding Proteins

Anti XBP1 [XBP2, TREB5] monoclonal antibody (clone : XBP1H6E5)


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Background

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein and was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has also been found that the same agents that cause an ER stress response, the unfolded protein response (UPR), also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. In the UPR pathway, two isoforms of the protein are made. The function of the shorter isoform (XBP-1U) has not been determined, while the longer isoform (XBP-1S) is the active isoform. The longer isoform is generated by a process in which two adjecent stem loop structures in the mRNA are recognized by IRE1, resulting in the loss of 26 nt from the mRNA and a frameshift in the CDS. Finally, a pseudogene has been identified and localized to chromosome 5. [NCBI Entrez Gene Summary]

Application

[Western Blot]
Western blot analysis of immunized recombinant protein, using anti-XBP1 monoclonal antibody.

Western_blot_protocolPDF

Product List

Product Name Cat# Quantity Price

Anti XBP1, Human (Mouse) Unlabeled DataSheet

CBX-CBX00292

100 UG ¥39,000
$520

“Anti XBP1 [XBP2, TREB5] monoclonal antibody (clone : XBP1H6E5)” also belongs to the following categories.