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useful for the research of various activities which high molecular hyaluronic acid does not have

Hyaluronic Acid Oligosaccharides (explanation on HA Products)


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Background

Hyaluronic acid is one of glycosaminoglycan, which does not include sulfate ester function, and it is isolated from the vitreous body of cow’s eye by Dr. Karl Meyer and his assistant Dr. John Palmer in 1934. Hyaluronic acid is constructed from disaccharide repeating units each consisting of a D-glucronic acid and N-acetyl-D-glucosamine, and it is said that the disaccharide repeating units are 10,000 or more in hyaluronic acid, which exist in a living body. Hyaluronic acid exist in almost all of vertebrate, and distributed in all parts of body, especially distributed in vitreous body, synovial fluid, skin, egg cell, brain and so on. Biological features of high molecular hyaluronic acid is water-retention, maintenance of cell, differentiation control and so on.
Recently, low molecular hyaluronic acid and hyaluronan oligosaccharide become known to have various activities which high molecular hyaluronic acid does not have. As shown in reference 1, recent many papers show that by changing molecular weight the product exhibits quite opposite activities.
For example, HA6 shows “Induction of NO and MMPs in chondrocytes”. PG Research has isolated and purified these hyaluronic acid oligosaccharides (HA Oligosaccharides) as shown below to have endotoxicin-free Oligosaccharides, and has been presenting them for in vitro use.

<Reference>
1. Stern R, et.al. Eur. J. Cell. Biol.85 (2006) 699-715
2. Tawada A, et.al. Glycobiology, 2002; 12(7),421


Fluoresce inamine labeled Sodium Hyaluronate flyer download [PDF]
Product List

Hyaluronan Oligosaccharide 4mer (HA4)

Hyaluronan Oligosaccharide 4mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)2β1→3GlcNAc

Molecular Weight: 820


Product Name Cat# Quantity Price

Hyaluronan Oligosaccharide 4mer (HA4) DataSheet ,

CSR-11001

3 MG ¥24,000
$320

Hyaluronan Oligosaccharide 4mer (HA4), Endotoxin Free DataSheet ,

CSR-11006

3 MG ¥55,000
$734

Hyaluronan Oligosaccharide 6mer (HA6)

Hyaluronan Oligosaccharide 6mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)2β1→3GlcNAc

Molecular Weight: 1221.29


Product Name Cat# Quantity Price

Hyaluronan Oligosaccharide 6mer (HA6) DataSheet ,

CSR-11002

3 MG ¥24,000
$320

Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free DataSheet ,

CSR-11007

3 MG ¥55,000
$734

Hyaluronan Oligosaccharide 8mer (HA8)

Hyaluronan Oligo saccharide 8mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)3β1→3GlcNAc

Molecular Weight: 1607.21


Product Name Cat# Quantity Price

Hyaluronan Oligosaccharide 8mer (HA8) DataSheet ,

CSR-11003

3 MG ¥29,000
$387

Hyaluronan Oligosaccharide 8mer (HA8), Endotoxin Free DataSheet ,

CSR-11008

3 MG ¥70,000
$934

Hyaluronan Oligosaccharide 10mer (HA10)

Hyaluronan Oligo saccharide 10mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)4β1→3GlcNAc

Molecular Weight: 1992.51


Product Name Cat# Quantity Price

Hyaluronan Oligosaccharide 10mer (HA10) DataSheet ,

CSR-11004

3 MG ¥37,000
$494

Hyaluronan Oligosaccharide 10mer (HA10), Endotoxin Free DataSheet ,

CSR-11009

3 MG ¥80,000
$1067

Hyaluronan Oligosaccharide 12mer (HA12)

Hyaluronan Oligo saccharide 12mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)5β1→3GlcNAc

Molecular Weight: 2393.81


Product Name Cat# Quantity Price

Hyaluronan Oligosaccharide 12mer (HA12) DataSheet ,

CSR-11005

1 MG ¥42,000
$560

Hyaluronan Oligosaccharide 12mer (HA12), Endotoxin Free DataSheet ,

CSR-11010

1 MG ¥72,000
$960

Hyaluronan oligosaccharide assortment(HA4, HA6, HA8, HA10, HA12)

Hyaluronan Oligo saccharide assortment (6-12mer) sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)nβ1→3GlcNAc


Product Name Cat# Quantity Price

Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12) DataSheet ,

CSR-93001

1 SET ¥125,000
$1667

Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12), Endotoxin Free DataSheet ,

CSR-93002

1 SET ¥270,000
$3600

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