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LINEAR NF-ƒČB Decoy Oligonucleotides Kits and RIBBON NF-ƒČB Decoy Oligonucleotides Kits


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Background

Painful inflammatory diseases such as rheumatoid arthritis and atopic dermatitis are currently treated primarily symptomatically, through the use of analgesics. Thus, there is a great need for novel therapeutics targeting the underlying inflammatory mechanisms. NF-κB is an intensively studied transcription factor well known for its role in stimulating the production of inflammatory cytokines. Recently, NF-κB decoy nucleic acids have gained considerable attention as potential therapeutics for inflammatory disease due to their ability to inhibit NFκB-mediated production of inflammatory cytokines, by preventing NF-κB from binding to its native DNA binding sites. Preliminary studies with NF-κB decoys indicate efficacy in reducing both pain and itch.

First generation NF-κB decoy nucleic acid drugs were linear DNA duplexes. Such drugs suffered not only from poor cellular uptake, but also from serum half-life due to poor resistance to nucleases. Subsequently, a circular (ribbon) form of NF-κB decoy was developed with improved nuclease resistance and significantly longer half-life.

Kit component

Offered here are NF-κB decoy oligodeoxynucleotides kits for our own research. Each kit contains the specified oligo and a control oligo with an identical base composition but different sequence that does not bind NF-κB. Phosphorotioate-modified kits are also offered. Please see the individual product datasheets for exact specifications. All oligos are purified by HPLC

 

Product List

Product Name Cat# Quantity Price

RIBBON NF(κ)B Decoy Oligonucleotides Kit DataSheet ,

GDS-DN-25101

2*0.5 MG ¥65,000
$867

RIBBON NF(κ)B Decoy Oligonucleotides Kit DataSheet ,

GDS-DN-25102

2*0.5 MG ¥75,000
$1000

NF(κ)B decoy Oligonucleotides Kit DataSheet ,

GDS-DN-15101

2*1 MG ¥45,000
$600

NF(κ)B decoy Oligonucleotides Kit DataSheet ,

GDS-DN-15102

2*1 MG ¥55,000
$734

NF(κ)B decoy Oligonucleotides Kit DataSheet ,

GDS-DN-15103

2*1 MG N/A

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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